DOCK8 and CDC42

Number of citations of the paper that reports this interaction (PMID 15304341)
13

Data Source:
HPRD (two hybrid)

		DOCK8	CDC42
Gene Name		dedicator of cytokinesis 8	cell division cycle 42
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Golgi Membrane Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Secretory Granule Filopodium Midbody Leading Edge Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Apical Part Of Cell Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process	Sprouting Angiogenesis Cardiac Conduction System Development Keratinocyte Development Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Actin Cytoskeleton Organization Macrophage Differentiation Hair Follicle Morphogenesis Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein Complex Assembly Keratinization Regulation Of Protein Stability Positive Regulation Of Cytokinesis Positive Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Organization Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Muscle Cell Differentiation Regulation Of Protein Heterodimerization Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Metalloenzyme Activity Neuron Fate Determination Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Canonical Wnt Signaling Pathway Submandibular Salivary Gland Formation Epithelial-mesenchymal Cell Signaling Hair Follicle Placode Formation Positive Regulation Of Hair Follicle Cell Proliferation Organelle Transport Along Microtubule Actin Filament Branching Epithelial Cell-cell Adhesion Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by GPCR Costimulation by the CD28 family Axon guidance DCC mediated attractive signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Inactivation of Cdc42 and Rac Rho GTPase cycle EPHB-mediated forward signaling EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Sema4D induced cell migration and growth-cone collapse Regulation of actin dynamics for phagocytic cup formation Innate Immune System EGFR downregulation CDO in myogenesis Semaphorin interactions CD28 co-stimulation Signaling by Ligand-Responsive EGFR Variants in Cancer Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by EGFR GPCR downstream signaling Myogenesis Signaling by VEGF Signaling by Rho GTPases Signaling by EGFR in Cancer GPVI-mediated activation cascade Platelet activation, signaling and aggregation Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)	Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	144 interactors: A2M ACTR3 AHSG ANXA2 APOH ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF25 ARHGEF6 ARHGEF7 ARRB1 ARRB2 BAIAP2 BCR BNIP2 BNIPL C14orf1 CASP3 CASP7 CBLL1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC42SE2 CDH1 CDKN1A CFHR4 CNTNAP1 COX1 CPN1 CSN2 CSPG4 DEF6 DIAPH2 DIAPH3 DOCK7 DOCK8 DOCK9 EEF1G EIF2AK2 ERRFI1 ETFA FGD1 FGD3 FLNA FMNL2 FNBP1 GDI1 GOPC GRB2 HERC2 IQGAP1 IQGAP2 ITSN1 KAT5 KIAA2026 KTN1 LCK LGALS1 LRIF1 MAP3K10 MAP3K11 MAP3K4 MARK4 MCF2 MCF2L MCM3AP METAP2 MUC12 MYO6 MYO9A NCF2 NEK6 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PARD3 PARD6A PARD6B PARD6G PDE6D PGGT1B PIK3R1 PLD1 PLEKHG2 PRKCA PRKCG PRKCI PRKCZ RAC1 RAC2 RAP1GDS1 RHOJ RIOK3 RPL22 RPL23 RPS6KB1 S100A9 SH3D19 SRGAP1 SSX2IP ST13 STAU1 SYNE1 TBC1D3F TNK2 TP53 TRAF2 TRIP10 UBR1 UNC119 USP6 VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 ZNF175 ZNF234 ZNF420
Entrez ID		81704	998
HPRD ID		10920	00309
Ensembl ID		ENSG00000107099	ENSG00000070831
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	B4E1U9 E7ETU3 P60953
PDB IDs			1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division	Regulation Of Catalytic Activity Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Metabolic Process Signaling Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Cell Communication Positive Regulation Of Ras GTPase Activity Cytoskeleton Organization Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Response To Stimulus Regulation Of Ras GTPase Activity Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Cell Death Death Neurotrophin Signaling Pathway Programmed Cell Death Rho Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Death Response To Growth Factor Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Endocytosis Locomotion Positive Regulation Of Apoptotic Process
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain
Tagcloud (Intersection) ?