DOCK8 and MTG1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK8	MTG1
Gene Name		dedicator of cytokinesis 8	mitochondrial ribosome-associated GTPase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Ribosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity GTP Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process	Regulation Of Respiratory System Process Regulation Of Mitochondrial Translation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	4 interactors: APP DOCK8 PRNP STRN4
Entrez ID		81704	92170
HPRD ID		10920	11602
Ensembl ID		ENSG00000107099	ENSG00000148824
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	E7EVK2 Q9BT17 U3KQ69
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division	Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cell Recognition Memory T Cell Proliferation Transition Metal Ion Homeostasis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Locomotion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Copper Ion Movement Of Cell Or Subcellular Component Axon Choice Point Recognition Negative Regulation Of Calcium-mediated Signaling Neuron Remodeling Negative Regulation Of Interleukin-17 Production Axon Guidance Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Metal Ion Homeostasis Response To Oxidative Stress Blood Coagulation Hemostasis Negative Regulation Of Activated T Cell Proliferation Cellular Cation Homeostasis Immunological Synapse Formation Single-organism Behavior Cellular Ion Homeostasis Metal Ion Homeostasis Axonogenesis Cellular Chemical Homeostasis Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Receptor Signaling Pathway Ion Homeostasis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Copper Ion Behavior Wound Healing Chemotaxis Suckling Behavior Dendritic Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Negative Regulation Of T Cell Apoptotic Process Cell Activation
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	18s 40s actb b2m cathelicidin cows csn2 gapdh genorm glyceraldehyde icg lactating lactation lactoferrin ltf microglobulin milk multiparous normfinder packages ppp1r11 qpcr rn18s1 rps15a s15a sahiwal suitability ubc uxt
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	18s 40s actb b2m cathelicidin cows csn2 gapdh genorm glyceraldehyde icg lactating lactation lactoferrin ltf microglobulin milk multiparous normfinder packages ppp1r11 qpcr rn18s1 rps15a s15a sahiwal suitability ubc uxt
Tagcloud (Intersection) ?