MAP1LC3B and FYCO1

Number of citations of the paper that reports this interaction (PMID 23043107)
9

Data Source:
BioGRID (unspecified method)

		MAP1LC3B	FYCO1
Gene Name		microtubule-associated protein 1 light chain 3 beta	FYVE and coiled-coil domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Lysosome Late Endosome Autophagic Vacuole Membrane Integral Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Microtubule Binding GABA Receptor Binding	Protein Binding Metal Ion Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Plus-end-directed Vesicle Transport Along Microtubule
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2	5 interactors: APP KDM1A MAP1LC3B PRMT6 RAF1
Entrez ID		81631	79443
HPRD ID		14358	06215
Ensembl ID		ENSG00000140941	ENSG00000163820
Uniprot IDs		H6UMI0 Q658J6 Q9GZQ8	B7ZKT7 Q9BQS8
PDB IDs		1V49 2LUE 2ZJD 3VTU 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation	Blood Coagulation Hemostasis Response To Stress Regulation Of Body Fluid Levels Wound Healing Death-inducing Signaling Complex Assembly Regulation Of Primitive Erythrocyte Differentiation Response To Wounding Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Histone H3-R2 Methylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Collateral Sprouting In Absence Of Injury Platelet Activation Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Axon Choice Point Recognition Organelle Organization Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cellular Protein Modification Process Neuron Remodeling Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Proteolysis Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Protein Processing Positive Regulation Of Hormone Biosynthetic Process Regulation Of Endopeptidase Activity Axon Guidance Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Differentiation Histone Modification Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Processing Histone H4-R3 Methylation Regulation Of Peptidase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?