Wiki-Pi
About
Search
People
Updates
Search
BNIP3 and CLN8
Number of citations of the paper that reports this interaction (PubMedID
23142642
)
0
Data Source:
BioGRID
(two hybrid)
BNIP3
CLN8
Description
BCL2 interacting protein 3
CLN8 transmembrane ER and ERGIC protein
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Envelope
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Postsynaptic Density
Membrane
Dendrite
Mitochondrial Membrane
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Presynapse
Molecular Function
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
GTPase Binding
Endoplasmic Reticulum-autophagosome Adaptor Activity
Mitochondrion Autophagosome Adaptor Activity
Protein Binding
Ceramide Binding
Biological Process
Autophagy Of Mitochondrion
Mitophagy
Response To Hypoxia
Apoptotic Process
Response To Bacterium
Positive Regulation Of Autophagy
Negative Regulation Of Mitochondrial Fusion
Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Macroautophagy
Cerebral Cortex Development
Mitochondrial Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Protein-containing Complex Disassembly
Mitochondrial Fragmentation Involved In Apoptotic Process
Negative Regulation Of Membrane Potential
Regulation Of Mitochondrial Membrane Permeability
Autophagic Cell Death
Response To Axon Injury
Oligodendrocyte Differentiation
Brown Fat Cell Differentiation
Neuron Apoptotic Process
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Defense Response To Virus
Response To Hyperoxia
Reticulophagy
Substrate Localization To Autophagosome
Cellular Response To Hydrogen Peroxide
Cellular Response To Mechanical Stimulus
Cellular Response To Cobalt Ion
Cellular Response To Hypoxia
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Response To Oxygen-glucose Deprivation
Intrinsic Apoptotic Signaling Pathway
Mitochondrial Outer Membrane Permeabilization
Granzyme-mediated Programmed Cell Death Signaling Pathway
Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Autophagy Of Mitochondrion
Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Phospholipid Metabolic Process
Ceramide Metabolic Process
Lipid Transport
Apoptotic Process
Mitochondrial Membrane Organization
Lysosome Organization
Nervous System Development
Visual Perception
Adult Walking Behavior
Cholesterol Metabolic Process
Associative Learning
Adult Locomotory Behavior
Regulation Of Cell Size
Lipid Biosynthetic Process
Macromolecule Catabolic Process
Spinal Cord Motor Neuron Differentiation
Somatic Motor Neuron Differentiation
Protein Catabolic Process
Social Behavior
Negative Regulation Of Neuron Apoptotic Process
Photoreceptor Cell Maintenance
Negative Regulation Of Proteolysis
Ceramide Biosynthetic Process
Musculoskeletal Movement
Neuromuscular Process Controlling Posture
Neuromuscular Process Controlling Balance
Neuron Apoptotic Process
Glutamate Reuptake
Lipid Homeostasis
Retina Development In Camera-type Eye
Neurofilament Cytoskeleton Organization
Retinal Rod Cell Apoptotic Process
Pathways
Drugs
Diseases
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Metabolite levels (
23823483
)
Eye morphology (
29921221
)
Gaucher disease severity (
22388998
)
Systolic blood pressure (
30224653
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Interacting Genes
71 interacting genes:
AGTR1
AMIGO1
ARL13B
BCL2
BCL2L1
BCL2L2
BIK
BNIP2
BNIP3L
CD3E
CD47
CLDN9
CLEC7A
CLN8
CMTM5
CREB3
CREB3L1
EBAG9
EBP
ELOVL4
ERGIC3
FAM209A
FAM241B
FATE1
FBXL4
FFAR2
FXYD6-FXYD2
GPR152
GPR37
GPR42
HIF1A
HIVEP1
HPN
HTR2B
IFNGR2
JAGN1
KTN1
LDLRAD1
LMNA
MALL
MAP1LC3B
MS4A3
NCBP1
OPA1
PLP2
PPTC7
REEP2
RHEB
RNASEK
RNF24
RPRM
SCN3B
SEC22A
SEC23A
SLC31A2
SLC35B1
SLC6A17
SLC71A2
SMIM3
SPACA1
TGM2
TLCD4
TM4SF18
TMEM101
TMEM106C
TMEM11
TMEM205
TMPRSS2
TMX2
TNMD
ZDHHC15
31 interacting genes:
ARL6IP5
BNIP3
BNIP3L
CD9
CYB5B
ERG28
FZD7
GABARAPL2
GPM6B
MTX1
NDRG2
PDIA6
PLP1
PLP2
PTPRN
RRP15
RTN4
SELENOK
SPCS2
STX8
TMEM107
TMEM11
TMEM128
TMEM134
TMEM147
TMEM14A
TUBB4A
UBC
USP40
YIPF6
ZUP1
Entrez ID
664
2055
HPRD ID
04482
06383
Ensembl ID
ENSG00000176171
ENSG00000182372
Uniprot IDs
Q12983
Q6NVY4
Q9UBY8
PDB IDs
2J5D
2KA1
2KA2
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Bcl-2 Family Protein Complex
Protein Binding
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Mitochondrial Outer Membrane
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Mitochondrial Membrane Organization
Apoptotic Mitochondrial Changes
Negative Regulation Of Apoptotic Process
Mitochondrial Membrane
Mitochondrion Organization
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Release Of Cytochrome C From Mitochondria
Dendritic Cell Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Apoptotic Process
Golgi Membrane
Negative Regulation Of Autophagy
Regulation Of Programmed Cell Death
Release Of Cytochrome C From Mitochondria
Regulation Of Intrinsic Apoptotic Signaling Pathway
BH3 Domain Binding
Apoptotic Process
Membrane Organization
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Programmed Cell Death
Cell Death
Positive Regulation Of Cell Maturation
Negative Regulation Of Dendritic Cell Apoptotic Process
Channel Activity
Regulation Of Response To Endoplasmic Reticulum Stress
Ceramide Binding
Transmembrane Transport
Chemical Homeostasis
Mitochondrion
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum
Membrane
Negative Regulation Of Membrane Potential
Negative Regulation Of Mitochondrial Membrane Potential
Mitochondrial Membrane Organization
Membrane Organization
Myelin Sheath
Mitochondrial Outer Membrane
Mitochondrion Organization
Mitochondrial Outer Membrane Permeabilization
Mitochondrial Protein Catabolic Process
Regulation Of Mitochondrial Membrane Permeability
Structural Constituent Of Myelin Sheath
Regulation Of Membrane Permeability
Central Nervous System Myelination
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Mitochondrial Envelope
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Response To Oxidative Stress
Negative Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Membrane Permeability
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Membrane Permeability
Glial Cell Migration
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?