BNIP3 and PPTC7

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		BNIP3	PPTC7
Description		BCL2 interacting protein 3	protein phosphatase targeting COQ7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Postsynaptic Density Membrane Dendrite Mitochondrial Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding Endoplasmic Reticulum-autophagosome Adaptor Activity Mitochondrion Autophagosome Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Apoptotic Process Response To Bacterium Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Cerebral Cortex Development Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Response To Axon Injury Oligodendrocyte Differentiation Brown Fat Cell Differentiation Neuron Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Defense Response To Virus Response To Hyperoxia Reticulophagy Substrate Localization To Autophagosome Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxygen-glucose Deprivation Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia	Mitophagy Regulation Of Ubiquinone Biosynthetic Process Negative Regulation Of Mitophagy Positive Regulation Of Ubiquinone Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolite levels ( 23823483)
Interacting Genes		71 interacting genes: AGTR1 AMIGO1 ARL13B BCL2 BCL2L1 BCL2L2 BIK BNIP2 BNIP3L CD3E CD47 CLDN9 CLEC7A CLN8 CMTM5 CREB3 CREB3L1 EBAG9 EBP ELOVL4 ERGIC3 FAM209A FAM241B FATE1 FBXL4 FFAR2 FXYD6-FXYD2 GPR152 GPR37 GPR42 HIF1A HIVEP1 HPN HTR2B IFNGR2 JAGN1 KTN1 LDLRAD1 LMNA MALL MAP1LC3B MS4A3 NCBP1 OPA1 PLP2 PPTC7 REEP2 RHEB RNASEK RNF24 RPRM SCN3B SEC22A SEC23A SLC31A2 SLC35B1 SLC6A17 SLC71A2 SMIM3 SPACA1 TGM2 TLCD4 TM4SF18 TMEM101 TMEM106C TMEM11 TMEM205 TMPRSS2 TMX2 TNMD ZDHHC15	4 interacting genes: BCL6 BNIP3 PBXIP1 ZDHHC17
Entrez ID		664	160760
HPRD ID		04482	18141
Ensembl ID		ENSG00000176171	ENSG00000196850
Uniprot IDs		Q12983 Q6NVY4	Q8NI37
PDB IDs		2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bcl-2 Family Protein Complex Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Mitochondrial Membrane Mitochondrion Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Release Of Cytochrome C From Mitochondria Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Golgi Membrane Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Apoptotic Process Membrane Organization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Programmed Cell Death Cell Death Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Ceramide Binding Transmembrane Transport Chemical Homeostasis Mitochondrion	Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mast Cell Cytokine Production Hemopoiesis Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation DNA-binding Transcription Factor Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Mitochondrion Autophagosome Adaptor Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Gene Expression Involved In Extracellular Matrix Organization Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Isotype Switching Pyramidal Neuron Differentiation Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Autophagic Cell Death Protein-cysteine S-myristoyltransferase Activity Articular Cartilage Development Plasma Cell Differentiation Negative Regulation Of B Cell Differentiation Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein-cysteine S-stearoyltransferase Activity Paraspeckles T-helper 2 Cell Differentiation Type 2 Immune Response Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of DNA-templated DNA Replication Negative Regulation Of Type 2 Immune Response Germinal Center Formation Regulation Of Memory T Cell Differentiation Regulation Of Germinal Center Formation Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Muscle Cell Apoptotic Process Mitochondrial Protein Catabolic Process Response To Oxygen-glucose Deprivation Regulation Of Mitochondrial Fusion Response To Cobalt Ion Striated Muscle Cell Apoptotic Process Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
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