PABPN1 and LATS1

Number of citations of the paper that reports this interaction (PMID 24107629)
5

Data Source:
BioGRID (unspecified method)

		PABPN1	LATS1
Gene Name		poly(A) binding protein, nuclear 1	large tumor suppressor kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex	Spindle Pole Microtubule Organizing Center Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Processing Muscle Contraction RNA Splicing Gene Expression Poly(A)+ MRNA Export From Nucleus Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle MRNA 3'-end Processing Modification By Virus Of Host MRNA Processing	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		mRNA Splicing Inhibition of Host mRNA Processing and RNA Silencing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region Host Interactions with Influenza Factors mRNA 3'-end processing Processing of Intronless Pre-mRNAs Influenza Infection NS1 Mediated Effects on Host Pathways Processing of Capped Intronless Pre-mRNA RNA Polymerase II Transcription Termination	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CARM1 DNAJB4 HNRNPA1 IL7R LATS1 PRMT3 SMARCA4 SNW1 STAU1 TNPO1 YWHAQ	43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX
Entrez ID		8106	9113
HPRD ID		03787	09147
Ensembl ID			ENSG00000131023
Uniprot IDs		Q86U42	O95835
PDB IDs		3B4D 3B4M 3UCG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Process Positive Regulation By Host Of Viral Transcription Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Peptidyl-arginine N-methylation Regulation Of Viral Process Histone Arginine Methylation Peptidyl-arginine Methylation Viral Process Interaction With Symbiont Positive Regulation Of Viral Transcription Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Viral Transcription Histone H3-R17 Methylation Histone Modification Methylation Keratinocyte Differentiation Chromosome Organization Positive Regulation Of Vitamin D Receptor Signaling Pathway Interleukin-7-mediated Signaling Pathway Histone H3-R2 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Positive Regulation By Virus Of Viral Protein Levels In Host Cell Histone Methylation Nuclear Import Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation DNA Methylation On Cytosine Within A CG Sequence Epidermal Cell Differentiation RNA Localization Negative Regulation Of T Cell Mediated Cytotoxicity Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Protein Methylation Cellular Localization Intrinsic Apoptotic Signaling Pathway Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Response To Organic Substance Chromatin Organization Intracellular Receptor Signaling Pathway Regulation Of Cell Differentiation Skin Development MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Intracellular MRNA Localization Regulation Of Signal Transduction Homeostasis Of Number Of Cells	Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		advances appreciated atypical avoid avoidance awareness biopsy cardinal chinese confusion decade dysphagia dystrophy earlier hoped investigations judicious last muscle muscular oculopharyngeal professionals proximal ptosis reserved rule underdiagnosed unnecessary weakness	accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Difference) ?		advances appreciated atypical avoid avoidance awareness biopsy cardinal chinese confusion decade dysphagia dystrophy earlier hoped investigations judicious last muscle muscular oculopharyngeal professionals proximal ptosis reserved rule underdiagnosed unnecessary weakness	accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Intersection) ?