PABPN1 and SNW1

Number of citations of the paper that reports this interaction (PubMedID 11371506)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PABPN1	SNW1
Description		poly(A) binding protein nuclear 1	SNW domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Inclusion Body Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly(A) Binding RNA Polymerase Binding	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Nuclear Vitamin D Receptor Binding Nuclear Retinoic Acid Receptor Binding SMAD Binding Nuclear Androgen Receptor Binding
	Biological Process	MAPK Cascade RNA Processing MRNA Processing Muscle Contraction Poly(A)+ MRNA Export From Nucleus Cellular Response To Lipopolysaccharide Positive Regulation Of Polynucleotide Adenylyltransferase Activity	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways		Inhibition of Host mRNA Processing and RNA Silencing mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Z-decay: degradation of maternal mRNAs by zygotically expressed factors Nuclear RNA decay	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases		Oculopharyngeal muscular dystrophy (OPMD)
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 26865924) Lymphocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Interacting Genes		15 interacting genes: CARM1 DNAJB4 HNRNPA1 HSP90AA1 IL7R LATS1 LINC00839 MYCBP2 OGT PRMT3 SMARCA4 SNW1 STAU1 TNPO1 YWHAQ	122 interacting genes: ABLIM3 ACTN2 APOBEC3C AR ASCC2 BAG4 BCAS2 BICD2 BYSL C1orf216 CCDC125 CEBPA CEP55 CEP70 CIRSR CPSF7 CSDE1 CTBP1 CWF19L2 DAXX DMRTB1 EP300 ERCC3 EXOSC5 EXOSC7 EXOSC8 FAM90A1 FTSJ3 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT31 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NIN NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OGT OSTF1 PABPN1 PCBD2 PEG10 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBFOX2 RBL1 RBL2 RBM22 RBPJ RBPMS RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 THOC1 TNNT1 TOP1 TRAF1 TRAK1 TRIM15 TRIM23 TRIM55 TRIM63 TSNAXIP1 TTC14 TXNL4A USF1 USO1 VAV2 VDR VIM VPS39 WBP4 ZSCAN1
Entrez ID		8106	22938
HPRD ID		03787	04340
Ensembl ID		ENSG00000100836	ENSG00000100603
Uniprot IDs		G3V4T2 Q86U42	G3V3A4 Q13573
PDB IDs		3B4D 3B4M 3UCG	5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Protein-containing Complex Regulation Of Post-translational Protein Modification Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of Gene Expression Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Modification Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Transmembrane Transporter Binding Nuclear Androgen Receptor Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Synapse Assembly Histone Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Host-mediated Activation Of Viral Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Metabolic Process CTP Binding DATP Binding Positive Regulation Of Stem Cell Population Maintenance Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process	Nucleoplasm RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Domain Specific Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Cytoplasm Chromatin Binding Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II RNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process MRNA Splicing, Via Spliceosome
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