PABPN1 and TNPO1

Number of citations of the paper that reports this interaction (PubMedID 10688363)
62

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PABPN1	TNPO1
Description		poly(A) binding protein nuclear 1	transportin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Inclusion Body Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Nuclear Lumen Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly(A) Binding RNA Polymerase Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	MAPK Cascade RNA Processing MRNA Processing Muscle Contraction Poly(A)+ MRNA Export From Nucleus Cellular Response To Lipopolysaccharide Positive Regulation Of Polynucleotide Adenylyltransferase Activity	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport
Pathways		Inhibition of Host mRNA Processing and RNA Silencing mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Z-decay: degradation of maternal mRNAs by zygotically expressed factors Nuclear RNA decay	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases		Oculopharyngeal muscular dystrophy (OPMD)
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 26865924) Lymphocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Chronic obstructive pulmonary disease ( 30804561) Factor VIII levels ( 30586737) Height ( 31562340) Hemoglobin ( 32888494) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 29403010 32888494) Mean platelet volume ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 28957414 32888494) Serum albumin levels ( 29403010) vWF levels ( 30586737)
Interacting Genes		15 interacting genes: CARM1 DNAJB4 HNRNPA1 HSP90AA1 IL7R LATS1 LINC00839 MYCBP2 OGT PRMT3 SMARCA4 SNW1 STAU1 TNPO1 YWHAQ	19 interacting genes: ELAVL1 H2BC21 H3-4 HNRNPA1 HNRNPD NUP153 NUP214 NUP98 NXF1 PABPN1 RAN RANBP2 RGPD5 RNF10 RPL23A RPL5 RPS7 SRP19 ULK2
Entrez ID		8106	3842
HPRD ID		03787	04210
Ensembl ID		ENSG00000100836	ENSG00000083312
Uniprot IDs		G3V4T2 Q86U42	A0A7P0TBF0 Q92973
PDB IDs		3B4D 3B4M 3UCG	1QBK 2H4M 2OT8 2QMR 2Z5J 2Z5K 2Z5M 2Z5N 2Z5O 4FDD 4FQ3 4JLQ 4OO6 5J3V 5TQC 5YVG 5YVH 5YVI 7CYL 7VPW 8SGH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Protein-containing Complex Regulation Of Post-translational Protein Modification Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of Gene Expression Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Modification Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Transmembrane Transporter Binding Nuclear Androgen Receptor Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Synapse Assembly Histone Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Host-mediated Activation Of Viral Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Metabolic Process CTP Binding DATP Binding Positive Regulation Of Stem Cell Population Maintenance Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process	Nuclear Transport Nucleocytoplasmic Transport Import Into Nucleus Nuclear Export Nuclear Inclusion Body RNA Export From Nucleus RNA Transport Nuclear Pore Nucleobase-containing Compound Transport Protein Import Into Nucleus MRNA Transport Ribonucleoprotein Complex Protein Localization To Nucleus Establishment Of Protein Localization To Organelle RNA Binding Nuclear Envelope Cellular Localization Intracellular Transport Nuclear Pore Nuclear Basket Nucleoplasm Intracellular Protein Transport Establishment Of Localization In Cell Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Protein Localization To Organelle Establishment Of Protein Localization Nucleus Cytosolic Ribosome Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Regulation Of Nucleocytoplasmic Transport Protein Transport MRNA 3'-UTR Binding Cytosol Negative Regulation Of Ubiquitin Protein Ligase Activity Intracellular Protein Localization Nuclear Pore Complex Assembly MRNA Export From Nucleus Negative Regulation Of Ubiquitin-protein Transferase Activity Nuclear Export Signal Receptor Activity Ubiquitin Ligase Inhibitor Activity Nuclear Pore Organization MRNA Binding Nuclear Periphery Regulation Of RNA Export From Nucleus Regulation Of Intracellular Transport Pore Complex Assembly Protein-containing Complex Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Poly(A)+ MRNA Export From Nucleus
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