CUL5 and COPS6

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
HPRD (in vitro)

		CUL5	COPS6
Gene Name		cullin 5	COP9 signalosome subunit 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cul5-RING Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Response To Osmotic Stress Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Cytosolic Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Cullin Deneddylation Viral Process
Pathways		Signaling by ERBB2 Vif-mediated degradation of APOBEC3G Antigen processing: Ubiquitination & Proteasome degradation HIV Infection Host Interactions of HIV factors Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ANAPC11 ARIH2 ASB11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D3 DCUN1D4 DCUN1D5 GOLGA2 GPS1 NEDD8 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RNF7 SMAD2 SMURF1 SOX30 TCEB1 TCEB2 TGFBR1 UBE2F VHL	84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24
Entrez ID		8065	10980
HPRD ID		03444	16735
Ensembl ID		ENSG00000166266	ENSG00000168090
Uniprot IDs		Q93034	Q7L5N1
PDB IDs		3DPL 3DQV 4JGH
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Cellular Protein Modification Process Protein Modification By Small Protein Removal Cellular Protein Metabolic Process Protein Neddylation Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Catabolic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Proteolysis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cholesterol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Response To Hypoxia Activin Receptor Signaling Pathway Inactivation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Positive Regulation Of Dense Core Granule Biogenesis Protein Polyubiquitination Positive Regulation Of Viral Transcription Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Proliferation	Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death
Tagcloud ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?