CUL5 and PTPN5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CUL5	PTPN5
Gene Name		cullin 5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cul5-RING Ubiquitin Ligase Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Response To Osmotic Stress Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Cytosolic Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Signaling by ERBB2 Vif-mediated degradation of APOBEC3G Antigen processing: Ubiquitination & Proteasome degradation HIV Infection Host Interactions of HIV factors Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065)
Protein-Protein Interactions		33 interactors: ANAPC11 ARIH2 ASB11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D3 DCUN1D4 DCUN1D5 GOLGA2 GPS1 NEDD8 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RNF7 SMAD2 SMURF1 SOX30 TCEB1 TCEB2 TGFBR1 UBE2F VHL	11 interactors: CUL5 CXCL9 FAM58A FYN MAPK1 MAPK3 SNX4 TERF1 TMEM51 VTI1B ZBTB5
Entrez ID		8065	84867
HPRD ID		03444	01472
Ensembl ID		ENSG00000166266	ENSG00000110786
Uniprot IDs		Q93034	B7Z2F8 B7ZAF5 P54829 Q86TL3
PDB IDs		3DPL 3DQV 4JGH	2BIJ 2BV5 2CJZ
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Cellular Protein Modification Process Protein Modification By Small Protein Removal Cellular Protein Metabolic Process Protein Neddylation Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Catabolic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Proteolysis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cholesterol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Response To Hypoxia Activin Receptor Signaling Pathway Inactivation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Positive Regulation Of Dense Core Granule Biogenesis Protein Polyubiquitination Positive Regulation Of Viral Transcription Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Proliferation	Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Regulation Of Cellular Localization Regulation Of Golgi Organization Sensory Perception Of Pain Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Epidermal Growth Factor Viral Process Platelet Activation Response To Fibroblast Growth Factor Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process Phagocytosis Response To Exogenous DsRNA Fc Receptor Signaling Pathway Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Vesicle-mediated Transport Toll-like Receptor 10 Signaling Pathway Cellular Response To Peptide Hormone Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway
Tagcloud ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide
Tagcloud (Difference) ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide
Tagcloud (Intersection) ?