CUL5 and COPS4

Number of citations of the paper that reports this interaction (PubMedID 11337588)
0

Data Source:
HPRD (in vitro)

		CUL5	COPS4
Description		cullin 5	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity	Protein Binding DeNEDDylase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL	28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		8065	51138
HPRD ID		03444	09888
Ensembl ID		ENSG00000166266	ENSG00000138663
Uniprot IDs		Q93034	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule
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