CUL5 and RHOBTB2

Number of citations of the paper that reports this interaction (PMID 18835386)
8

Data Source:
BioGRID (two hybrid)

		CUL5	RHOBTB2
Gene Name		cullin 5	Rho-related BTB domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cul5-RING Ubiquitin Ligase Complex	Cytosol Plasma Membrane
	Molecular Function	Receptor Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	GTP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Response To Osmotic Stress Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Cytosolic Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by ERBB2 Vif-mediated degradation of APOBEC3G Antigen processing: Ubiquitination & Proteasome degradation HIV Infection Host Interactions of HIV factors Class I MHC mediated antigen processing & presentation Adaptive Immune System	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ANAPC11 ARIH2 ASB11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D3 DCUN1D4 DCUN1D5 GOLGA2 GPS1 NEDD8 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RNF7 SMAD2 SMURF1 SOX30 TCEB1 TCEB2 TGFBR1 UBE2F VHL	2 interactors: CUL5 RHOBTB3
Entrez ID		8065	23221
HPRD ID		03444	06300
Ensembl ID		ENSG00000166266	ENSG00000008853
Uniprot IDs		Q93034	A8K9Z8 E9PBU2 E9PEI7 Q9BYZ6
PDB IDs		3DPL 3DQV 4JGH
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Cellular Protein Modification Process Protein Modification By Small Protein Removal Cellular Protein Metabolic Process Protein Neddylation Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Catabolic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Proteolysis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cholesterol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Response To Hypoxia Activin Receptor Signaling Pathway Inactivation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Positive Regulation Of Dense Core Granule Biogenesis Protein Polyubiquitination Positive Regulation Of Viral Transcription Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Proliferation
Tagcloud ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming seq transcriptome verifying xenobiotic
Tagcloud (Difference) ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming seq transcriptome verifying xenobiotic
Tagcloud (Intersection) ?