CEP63 and ARFIP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CEP63	ARFIP2
Gene Name		centrosomal protein 63kDa	ADP-ribosylation factor interacting protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Ruffle Cytoplasm Plasma Membrane Cell Cortex Trans-Golgi Network Membrane
	Molecular Function	Protein Binding	Protein Binding GTP Binding Protein Domain Specific Binding GTP-dependent Protein Binding Rac GTPase Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division	Movement Of Cell Or Subcellular Component Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 18391952)
Protein-Protein Interactions		44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10	26 interactors: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 CDKN2A CEP63 DTNBP1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 LY6D MAL2 RAC1 RAC2 SNX1 SOCS2 STAT3 TRIM54 USHBP1
Entrez ID		80254	23647
HPRD ID		07826	07209
Ensembl ID		ENSG00000182923	ENSG00000132254
Uniprot IDs		Q96MT8	B4DUZ3 B4DXH2 P53365
PDB IDs			1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Signal Transduction Vesicle-mediated Transport Cell Projection Organization Response To Stimulus Regulation Of Signaling Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Organelle Organization Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Protein Localization Cellular Localization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Cell Death Apoptotic Process Platelet Activation Protein Transport Programmed Cell Death Regulation Of Hydrogen Peroxide Metabolic Process Blood Coagulation Cell Death Death Cell Division Establishment Of Protein Localization Hemostasis Regulation Of Respiratory Burst Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Positive Regulation Of Lamellipodium Assembly Generation Of Neurons Golgi Vesicle Transport Protein Localization To Organelle Positive Regulation Of Lamellipodium Organization Neurogenesis Cell Projection Morphogenesis Membrane Invagination Cellular Copper Ion Homeostasis Negative Regulation Of JAK-STAT Cascade Cell Part Morphogenesis Positive Regulation Of Signal Transduction Developmental Process
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