ARFIP2 and ARL1

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (two hybrid, proximity labelling technology, two hybrid, affinity chromatography technology)

		ARFIP2	ARL1
Description		ARF interacting protein 2	ARF like GTPase 1
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GO Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Activator Activity Protein Domain Specific Binding Metal Ion Binding Phospholipase D Activator Activity
	Biological Process	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site	Intracellular Protein Transport Golgi Organization Toxin Metabolic Process Vesicle-mediated Transport Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi
Pathways		Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Malaria ( 31844061)	Lung cancer in never smokers ( 28604730) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	8 interacting genes: ARFIP2 COPG2 DRD2 GCC1 GCC2 GOLGA1 GOLGA4 SCOC
Entrez ID		23647	400
HPRD ID		07209	04574
Ensembl ID		ENSG00000132254	ENSG00000120805
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	B4DZG7 P40616
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	1UPT 4DCN 5EE5 5J5C
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process	Golgi Apparatus Golgi Membrane Trans-Golgi Network Small GTPase Binding Golgi To Plasma Membrane Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Intracellular Protein Localization Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Secretion Vesicle-mediated Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Acrosomal Vesicle Cytosol Vesicle-mediated Transport To The Plasma Membrane Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Recycling Endosome To Golgi Transport Intracellular Protein Transport Membrane Curvature Sensor Activity Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Developmental Growth Late Endosome To Golgi Transport Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell
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