CEP63 and CCDC14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (proximity labelling technology, two hybrid, proximity labelling technology)

		CEP63	CCDC14
Description		centrosomal protein 63	coiled-coil domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	Cytoplasm Centrosome Cytoskeleton Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination	Substantia Nigra Development Protein Localization To Centrosome
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Intelligence (MTAG) ( 29326435)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	17 interacting genes: APP CALM1 CEP63 CSNK1D CSNK1E DDX6 KDM1A MAGEA11 MAGEB4 MAPK14 PEX5 PIK3R3 PLAC9 PNKP RNF8 TXLNB UBQLN4
Entrez ID		80254	64770
HPRD ID		07826	07801
Ensembl ID		ENSG00000182923	ENSG00000175455
Uniprot IDs		A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8	J3QT39 Q49A88
PDB IDs		6CSU 6CSV 7W91
Enriched GO Terms of Interacting Partners?		Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm	Regulation Of Double-strand Break Repair Regulation Of Canonical Wnt Signaling Pathway Response To Radiation DNA Damage Response Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Neuron Maturation Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Spindle Pole Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of DNA Recombination DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Cytosol Cellular Response To Nerve Growth Factor Stimulus Spindle Microtubule Regulation Of Proteasomal Protein Catabolic Process Concave Side Of Sperm Head Positive Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of DNA Metabolic Process Cellular Response To CAMP
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