CEP63 and CCDC14

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CEP63	CCDC14
Gene Name		centrosomal protein 63kDa	coiled-coil domain containing 14
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Centrosome
	Molecular Function	Protein Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division	Substantia Nigra Development
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 18391952)
Protein-Protein Interactions		44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10	9 interactors: APP CALM1 CEP63 KDM1A MAGEA11 MAPK14 PEX5 PLAC9 UBQLN4
Entrez ID		80254	64770
HPRD ID		07826	07801
Ensembl ID		ENSG00000182923	ENSG00000175455
Uniprot IDs		Q96MT8	Q49A88
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Erythrocyte Differentiation Platelet Activation Response To Wounding Brain Development Head Development Regulation Of Erythrocyte Differentiation Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Regulation Of Protein Metabolic Process Fatty Acid Oxidation Lipid Oxidation Mitochondrion Organization Platelet Degranulation Forebrain Development Positive Regulation Of Myeloid Cell Differentiation Response To Radiation Regulation Of Primitive Erythrocyte Differentiation P38MAPK Cascade Signal Transduction In Response To DNA Damage Regulation Of Multicellular Organism Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process Myeloid Leukocyte Differentiation Organ Development Neuromuscular Process Negative Regulation Of Protein Homotetramerization Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cellular Biosynthetic Process Organelle Organization Cellular Response To Radiation Glucose Metabolic Process Cell Activation Regulation Of Protein Binding Protein Import Into Peroxisome Matrix, Translocation Collateral Sprouting In Absence Of Injury DNA Damage Checkpoint Regulation Of Protein Kinase Activity Response To Stress Regulation Of Myeloid Cell Differentiation Protein Import Into Peroxisome Matrix, Docking Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Kinase Activity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Lipid Modification Myoblast Differentiation Involved In Skeletal Muscle Regeneration
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