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ARFIP2 and ITSN1
Number of citations of the paper that reports this interaction (PMID
22558309
)
5
Data Source:
BioGRID
(two hybrid, protein complementation assay, affinity chromatography technology)
ARFIP2
ITSN1
Gene Name
ADP-ribosylation factor interacting protein 2
intersectin 1 (SH3 domain protein)
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Plasma Membrane
Cell Cortex
Trans-Golgi Network Membrane
Cytosol
Plasma Membrane
Coated Pit
Lamellipodium
Cell Junction
Endocytic Vesicle
Neuron Projection
Synapse
Molecular Function
Protein Binding
GTP Binding
Protein Domain Specific Binding
GTP-dependent Protein Binding
Rac GTPase Binding
Phosphatidylinositol-4-phosphate Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Kinase Activator Activity
Protein Complex Scaffold
Proline-rich Region Binding
Biological Process
Movement Of Cell Or Subcellular Component
Small GTPase Mediated Signal Transduction
Lamellipodium Assembly
Actin Cytoskeleton Organization
Ruffle Organization
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Synaptic Vesicle Endocytosis
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
EPHB-mediated forward signaling
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions
26 interactors:
AGTRAP
AKT1
APP
ARF1
ARF3
ARF5
ARF6
ARL1
CDKN2A
CEP63
DTNBP1
HAUS1
HGS
ING5
ITGB3BP
ITSN1
KRT15
LY6D
MAL2
RAC1
RAC2
SNX1
SOCS2
STAT3
TRIM54
USHBP1
82 interactors:
AGFG1
AGFG2
AP2B1
ARF6
ARFIP2
ARHGAP31
ASAP2
CCNO
CDC42
CEP85L
CLIP2
CLTC
CSNK2B
CYTH1
DAB2
DES
DISC1
DLGAP1
DNM1
DNM2
EEF1A1
EPHB2
EPN2
EPS15
EPS15L1
FCHSD2
FNBP1
FNBP4
GAREML
GCC1
GOLGA5
HIP1
HRAS
ITSN2
KHDRBS1
KIF16B
KIF5A
LMO4
MAPK6
MAPK8IP2
MRPL20
MTUS2
PACSIN3
PDCD6IP
PFDN5
PICALM
PIK3AP1
PIK3C2B
PIK3R1
PLK1
PPFIA2
PPL
PREX1
RAB11FIP2
RAB5A
RABEP1
RAI14
RNF40
RPS6KA5
SCAMP1
SCOC
SF3B4
SH3GL2
SMARCC2
SNAP23
SNAP25
SNX5
SOS1
SPDL1
SPRY2
STON2
SYNJ1
SYNJ2
TK1
TRIM8
TSG101
UBE2K
UNC119
WASL
WBP11
ZAK
ZFPM2
Entrez ID
23647
6453
HPRD ID
07209
03898
Ensembl ID
ENSG00000132254
ENSG00000205726
Uniprot IDs
B4DUZ3
B4DXH2
P53365
A7XZY7
F8W7U0
Q15811
Q6PD56
PDB IDs
1I49
1I4D
1I4L
1I4T
4DCN
1KI1
2KGR
2KHN
3FIA
3QBV
4IIM
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Small GTPase Mediated Signal Transduction
Signaling
Cell Communication
Signal Transduction
Vesicle-mediated Transport
Cell Projection Organization
Response To Stimulus
Regulation Of Signaling
Cellular Response To Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Organelle Organization
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signal Transduction
Protein Localization
Cellular Localization
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Growth
Positive Regulation Of Cell Death
Apoptotic Process
Platelet Activation
Protein Transport
Programmed Cell Death
Regulation Of Hydrogen Peroxide Metabolic Process
Blood Coagulation
Cell Death
Death
Cell Division
Establishment Of Protein Localization
Hemostasis
Regulation Of Respiratory Burst
Intracellular Transport
Establishment Of Localization In Cell
Regulation Of Cell Death
Positive Regulation Of Lamellipodium Assembly
Generation Of Neurons
Golgi Vesicle Transport
Protein Localization To Organelle
Positive Regulation Of Lamellipodium Organization
Neurogenesis
Cell Projection Morphogenesis
Membrane Invagination
Cellular Copper Ion Homeostasis
Negative Regulation Of JAK-STAT Cascade
Cell Part Morphogenesis
Positive Regulation Of Signal Transduction
Developmental Process
Vesicle-mediated Transport
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Endocytosis
Vesicle Organization
Cellular Localization
Establishment Of Localization In Cell
Regulation Of Vesicle-mediated Transport
Signaling
Synaptic Transmission
Regulation Of Cellular Component Organization
Establishment Of Organelle Localization
Cell Communication
Regulation Of Signaling
Organelle Organization
Protein Localization
Cell Differentiation
Synaptic Vesicle Transport
Cell-cell Signaling
Membrane Budding
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Organelle Localization
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Metabolic Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Morphogenesis
Negative Regulation Of ERBB Signaling Pathway
Post-Golgi Vesicle-mediated Transport
Establishment Of Vesicle Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Vesicle Localization
Transport
Cell Morphogenesis Involved In Neuron Differentiation
Axon Guidance
Generation Of Neurons
Cell Morphogenesis Involved In Differentiation
Membrane Organization
Cell Projection Morphogenesis
Cell Part Morphogenesis
Establishment Of Protein Localization
Cell Projection Organization
Synaptic Vesicle Recycling
Axonogenesis
Cellular Protein Complex Assembly
Neurogenesis
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Intracellular Transport
Cell Morphogenesis
Tagcloud
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Difference)
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Intersection)
?