CEP63 and PPP4R1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		CEP63	PPP4R1
Description		centrosomal protein 63	protein phosphatase 4 regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	Cytoplasm Protein Phosphatase 4 Complex
	Molecular Function	Protein Binding Molecular Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination	Protein Phosphorylation Signal Transduction
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Lean body mass ( 28552196) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	6 interacting genes: CEP63 DISC1 DSCR9 HDAC3 PPP4C SASH1
Entrez ID		80254	9989
HPRD ID		07826	05366
Ensembl ID		ENSG00000182923	ENSG00000154845
Uniprot IDs		A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8	Q8TF05
PDB IDs		6CSU 6CSV 7W91
Enriched GO Terms of Interacting Partners?		Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm	Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Polyubiquitination Molecular Adaptor Activity Regulation Of Protein K63-linked Ubiquitination Microtubule Cytoskeleton Organization Positive Regulation Of Ferroptosis Spindle Assembly Neural Precursor Cell Proliferation Centrosome Regulation Of Protein Modification Process Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Regulation Of Protein Metabolic Process Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Spindle Organization Protein Decrotonylase Activity Histone Decrotonylase Activity Organelle Assembly Protein Phosphatase 4 Complex Positive Regulation Of Protein Metabolic Process Cornified Envelope Assembly Microtubule-based Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Protein Autoubiquitination Radial Glia-guided Pyramidal Neuron Migration Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Phosphorylation Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Protein Polyubiquitination Positive Regulation Of Phosphorylation Cytoskeleton Organization Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Cardiac Muscle Cell Differentiation Cellular Response To Parathyroid Hormone Stimulus Membraneless Organelle Assembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
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