ARFIP2 and RAC2

Number of citations of the paper that reports this interaction (PMID 11346801)
62

Data Source:
HPRD (in vitro)

		ARFIP2	RAC2
Gene Name		ADP-ribosylation factor interacting protein 2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
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Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell Cortex Trans-Golgi Network Membrane	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Protein Binding GTP Binding Protein Domain Specific Binding GTP-dependent Protein Binding Rac GTPase Binding Phosphatidylinositol-4-phosphate Binding	GTPase Activity GTP Binding
	Biological Process	Movement Of Cell Or Subcellular Component Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization	Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration
Pathways			Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		26 interactors: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 CDKN2A CEP63 DTNBP1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 LY6D MAL2 RAC1 RAC2 SNX1 SOCS2 STAT3 TRIM54 USHBP1	20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		23647	5880
HPRD ID		07209	03628
Ensembl ID		ENSG00000132254	ENSG00000128340
Uniprot IDs		B4DUZ3 B4DXH2 P53365	P15153
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Signal Transduction Vesicle-mediated Transport Cell Projection Organization Response To Stimulus Regulation Of Signaling Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Organelle Organization Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Protein Localization Cellular Localization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Cell Death Apoptotic Process Platelet Activation Protein Transport Programmed Cell Death Regulation Of Hydrogen Peroxide Metabolic Process Blood Coagulation Cell Death Death Cell Division Establishment Of Protein Localization Hemostasis Regulation Of Respiratory Burst Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Positive Regulation Of Lamellipodium Assembly Generation Of Neurons Golgi Vesicle Transport Protein Localization To Organelle Positive Regulation Of Lamellipodium Organization Neurogenesis Cell Projection Morphogenesis Membrane Invagination Cellular Copper Ion Homeostasis Negative Regulation Of JAK-STAT Cascade Cell Part Morphogenesis Positive Regulation Of Signal Transduction Developmental Process	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development
Tagcloud ?			aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Difference) ?			aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Intersection) ?