ARFIP2 and NDRG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARFIP2	NDRG4
Description		ARF interacting protein 2	NDRG family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Molecular_function Protein Binding
	Biological Process	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Malaria ( 31844061)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 19305408 19305409 22726844) Schizophrenia ( 29483656)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		23647	65009
HPRD ID		07209	14817
Ensembl ID		ENSG00000132254	ENSG00000103034
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization
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