CEP63 and SNRNP70

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CEP63	SNRNP70
Gene Name		centrosomal protein 63kDa	small nuclear ribonucleoprotein 70kDa (U1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Height ( 18391952)
Protein-Protein Interactions		44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10	43 interactors: APP ARSF CDKL3 CEP63 CHERP CLK2 CRP CSNK2A1 CTDP1 DDX17 GEMIN2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2
Entrez ID		80254	6625
HPRD ID		07826	01617
Ensembl ID		ENSG00000182923	ENSG00000104852
Uniprot IDs		Q96MT8	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process	RNA Processing RNA Metabolic Process Gene Expression MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cellular Macromolecular Complex Assembly Mesonephros Development Spliceosomal Complex Assembly Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Response To Growth Factor Kidney Epithelium Development Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Splicing Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Component Assembly Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Embryonic Pattern Specification Anatomical Structure Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of MRNA Processing
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