CEP63 and EXOC4

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CEP63	EXOC4
Gene Name		centrosomal protein 63kDa	exocyst complex component 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region
	Molecular Function	Protein Binding	Protein Binding Ral GTPase Binding PDZ Domain Binding Protein N-terminus Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS		Height ( 18391952)	Alzheimer's disease (cognitive decline) ( 23535033) Tonometry ( 17903302)
Protein-Protein Interactions		44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10	10 interactors: BIRC6 CEP63 DISC1 DLG3 DLG4 DLGAP4 DTNBP1 EXOC7 GRIN2B RALA
Entrez ID		80254	60412
HPRD ID		07826	12185
Ensembl ID		ENSG00000182923	ENSG00000131558
Uniprot IDs		Q96MT8	B7Z321 F5GZT1 Q6NX51 Q96A65
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process	Receptor Localization To Synapse Membrane Organization Cell-cell Signaling Protein Localization To Synapse Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Organelle Organization Synaptic Transmission Chemotaxis Locomotion Neuron Projection Morphogenesis Cellular Localization Movement Of Cell Or Subcellular Component Receptor Clustering Generation Of Neurons Regulation Of Synaptic Transmission Neuron Projection Development Nucleotide Phosphorylation Cell Projection Morphogenesis Signaling Cell Part Morphogenesis Neurogenesis Exocytosis Cell Communication Actin Cytoskeleton Reorganization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron Development Axon Guidance Post-Golgi Vesicle-mediated Transport Cell Division Cell Morphogenesis Neuron Differentiation Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Secretion By Cell Membrane Depolarization Axonogenesis Neuromuscular Process Nervous System Development Axon Development Learning Cell Morphogenesis Involved In Neuron Differentiation Membrane Raft Localization Actin Cytoskeleton Organization Secretion Actin Filament-based Process Vesicle-mediated Transport Regulation Of Synaptic Plasticity
Tagcloud ?			adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable
Tagcloud (Difference) ?			adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable
Tagcloud (Intersection) ?