CEP63 and CAPN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP63	CAPN7
Description		centrosomal protein 63	calpain 7
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Molecular Adaptor Activity	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Metabolite levels ( 23823483)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		80254	23473
HPRD ID		07826	05908
Ensembl ID		ENSG00000182923	ENSG00000131375
Uniprot IDs		A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8	Q7Z479 Q9Y6W3
PDB IDs		6CSU 6CSV 7W91	2QFE 8UC6
Enriched GO Terms of Interacting Partners?		Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm	Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
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