CEP63 and INTS6L

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		CEP63	INTS6L
Description		centrosomal protein 63	integrator complex subunit 6 like
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	Integrator Complex
	Molecular Function	Protein Binding Molecular Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination	SnRNA 3'-end Processing
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Hip circumference ( 28552196)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	2 interacting genes: CEP63 MAPK14
Entrez ID		80254	203522
HPRD ID		07826	06618
Ensembl ID		ENSG00000182923	ENSG00000165359
Uniprot IDs		A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8	A0A1W2PPI5 Q5JSJ4
PDB IDs		6CSU 6CSV 7W91
Enriched GO Terms of Interacting Partners?		Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm	Signal Transduction In Response To DNA Damage Spindle Pole DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Immune Response Negative Regulation Of Cell Cycle Process Negative Regulation Of Defense Response Regulation Of Synaptic Membrane Adhesion Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition NFAT Protein Binding Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Mitogen-activated Protein Kinase P38 Binding Stress-induced Premature Senescence Negative Regulation Of Immune System Process NLRP1 Inflammasome Complex Assembly Negative Regulation Of Protein Polyubiquitination Cellular Response To Lipoteichoic Acid Cell Aggregation Positive Regulation Of Myotube Differentiation Regulation Of Defense Response Negative Regulation Of Hippo Signaling 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Brown Fat Cell Differentiation Regulation Of Brown Fat Cell Differentiation P38MAPK Cascade Cellular Response To UV-B Response To UV-B DNA Damage Response D-glucose Import MAP Kinase Activity Positive Regulation Of Myoblast Fusion Cartilage Condensation MAP Kinase Kinase Activity Positive Regulation Of Cyclase Activity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Stress-activated MAPK Cascade Regulation Of Myoblast Fusion Regulation Of Cell Cycle Process Stress-activated Protein Kinase Signaling Cascade Response To Muramyl Dipeptide Response To Dietary Excess Centriole Replication Regulation Of Protein K63-linked Ubiquitination Response To Muscle Stretch Regulation Of Immune Response Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Vascular Endothelial Growth Factor Stimulus
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