ARFIP2 and SNX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ARFIP2	SNX1
Description		ARF interacting protein 2	sorting nexin 1
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GO Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane	Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Cell Projection
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site	Intracellular Protein Transport Protein Transport Endosomal Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	49 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ARMC12 ATXN7 CCDC148 CHRNG CMTM4 CMTM5 COQ3 EGFR F2R FAM25A FAM25C FAM25G FKBP7 FUNDC1 HCCS HGS INSR LEPR LIME1 MPC2 NRIP1 PDGFRB PLIN3 RABAC1 REEP5 REEP6 RHEX RTN3 RTN4 SASH1 SDCBP SDR16C5 SFT2D1 SH3GLB1 SNCA SNX2 SNX6 SYNGR1 SYP TK1 TMEM239 UFD1 VPS35
Entrez ID		23647	6642
HPRD ID		07209	03171
Ensembl ID		ENSG00000132254	ENSG00000028528
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	Q13596
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	2I4K 4FZS 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process	Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Formation Cellular Response To Growth Factor Stimulus Receptor Complex Regulation Of Long-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Membrane Organization Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Cell Migration PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vesicle-mediated Transport Regulation Of Transport Retromer Complex Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Cell Motility Activin Receptor Activity Cell Migration Involved In Vasculogenesis Retromer, Tubulation Complex Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Lysosome Identical Protein Binding Membrane Organization Positive Regulation Of Transport Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasmic Vesicle Tubular Endosome Activin Receptor Complex Regulation Of Locomotion Establishment Of Protein Localization Synapse Early Endosome Membrane Cadherin Binding Regulation Of Synaptic Plasticity Positive Regulation Of MAPK Cascade Neuron Projection Activin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Transmembrane Receptor Protein Serine/threonine Kinase Activity
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