ARFIP2 and SCAMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARFIP2	SCAMP1
Description		ARF interacting protein 2	secretory carrier membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane	Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Trans-Golgi Network Membrane Specific Granule Membrane Zymogen Granule Membrane Synapse Recycling Endosome Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport Establishment Of Localization In Cell
Pathways		Retrograde transport at the Trans-Golgi-Network	Neutrophil degranulation
Drugs
Diseases
GWAS		Malaria ( 31844061)	Hippocampal atrophy ( 19668339) Intraocular pressure ( 29785010) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglycerides ( 26780889)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	27 interacting genes: ARFIP1 ARFIP2 CFTR EGFR EPS15 GAD2 ITSN1 KRTAP13-1 MTERF3 NDRG4 PBX3 PCYT1A PTPN9 SCAMP2 SLC9A7 SNAP23 SNAP25 SNCA SPG21 SYNRG TASOR2 TBRG4 THAP4 TP53 TTPA UBE3A ZMIZ2
Entrez ID		23647	9522
HPRD ID		07209	06072
Ensembl ID		ENSG00000132254	ENSG00000085365
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	A0A087WXB0 B4E2V7 O15126
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process	Synaptic Vesicle Priming Regulation Of Golgi Lumen Acidification Cytosol Vesicle-mediated Transport In Synapse Exocytosis Import Into Cell Regulation Of Protein Localization Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle Docking Establishment Of Protein Localization Embryonic Organ Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Endosome Positive Regulation Of Receptor Recycling Organelle Localization By Membrane Tethering Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Locomotory Behavior Synaptic Vesicle Membrane Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular PH Membrane Docking Regulation Of Intracellular PH Vesicle-mediated Transport Secretion By Cell Intracellular Vesicle Regulation Of PH Recycling Endosome Membrane Post-Golgi Vesicle-mediated Transport Positive Regulation Of Protein Localization Endocytosis Regulation Of Receptor Recycling Embryonic Placenta Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Trans-Golgi Network Membrane Regulation Of Arp2/3 Complex-mediated Actin Nucleation Golgi Apparatus Neurotransmitter Uptake Phospholipid Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding Regulation Of Cellular Localization Recycling Endosome Positive Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen
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