SLC22A4 and PDZK1

Number of citations: 0 (PubMedID 14531806)
Data Source: HPRD (two hybrid, in vitro)

		SLC22A4	PDZK1
Name		solute carrier family 22 member 4	PDZ domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Mitochondrial Membrane Neuronal Cell Body	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Acetylcholine Transmembrane Transporter Activity Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity
	Biological Process	Sulfur Amino Acid Transport Triglyceride Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Lactation Carnitine Metabolic Process Quaternary Ammonium Group Transport Carnitine Transport Response To Lipopolysaccharide Response To Vitamin D Xenobiotic Transport Response To Exogenous DsRNA Acetylcholine Uptake Transmembrane Transport Amino Acid Import Across Plasma Membrane Liver Regeneration Carnitine Transmembrane Transport	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		SLC-mediated transport of organic cations	None
Drugs		Levocarnitine	None
Diseases		Crohn's disease	None
GWAS		Asthma ( 31619474 ) Asthma (sex interaction) ( 24824216 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 22412388 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Fibrinogen ( 20031577 ) Fibrinogen levels ( 26561523 ) Granulocyte count ( 27863252 ) Immature fraction of reticulocytes ( 27863252 ) Inflammatory bowel disease ( 28067908 23128233 ) Intracranial aneurysm ( 33199917 ) Itch intensity from mosquito bite ( 28199695 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 27863252 ) Metabolic traits ( 21886157 ) Monocyte count ( 27863252 ) Myeloid white cell count ( 27863252 ) Myocardial infarction ( 33532862 ) Nasal polyps ( 30643255 ) Neutrophil count ( 27863252 ) Platelet count ( 32888494 ) Serum metabolite levels ( 23093944 33031748 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) White blood cell count ( 27863252 )	Contrast sensitivity ( 24152035 ) Gout ( 32238385 33832965 ) Serum uric acid levels ( 30993211 ) Urate levels ( 20884846 23263486 31578528 31985003 ) Urate levels in overweight individuals ( 25811787 ) Uric acid levels ( 19503597 )
Novel Interactors		1 novel interactors: PVR	None recorded
Interacting Genes		4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1	30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		6583	5174
HPRD ID		09171	04829
Ensembl ID		ENSG00000197208	ENSG00000174827
Uniprot IDs		Q9H015	B2R7S7 Q5T2W1
PDB IDs		Not available	2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
GO Terms Enriched among Interactors		Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Brush Border Membrane Phosphatase Binding Brush Border PDZ Domain Binding Cellular Localization Apical Part Of Cell Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Beta-catenin Binding Intracellular Protein Localization Susceptibility To T Cell Mediated Cytotoxicity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Susceptibility To Natural Killer Cell Mediated Cytotoxicity Scavenger Receptor Binding Molecular Adaptor Activity Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Endomembrane System Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport	Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH