SLC22A4 and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		SLC22A4	NHERF2
Description		solute carrier family 22 member 4	NHERF family PDZ scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Mitochondrial Membrane Neuronal Cell Body	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Acetylcholine Transmembrane Transporter Activity Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Sulfur Amino Acid Transport Triglyceride Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Lactation Carnitine Metabolic Process Quaternary Ammonium Group Transport Carnitine Transport Response To Lipopolysaccharide Response To Vitamin D Xenobiotic Transport Response To Exogenous DsRNA Acetylcholine Uptake Transmembrane Transport Amino Acid Import Across Plasma Membrane Liver Regeneration Carnitine Transmembrane Transport	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		SLC-mediated transport of organic cations
Drugs		Levocarnitine
Diseases		Crohn's disease
GWAS		Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Itch intensity from mosquito bite ( 28199695) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Platelet count ( 32888494) Serum metabolite levels ( 23093944 33031748) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)
Interacting Genes		4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		6583	9351
HPRD ID		09171	05946
Ensembl ID		ENSG00000197208	ENSG00000065054
Uniprot IDs		Q9H015	H3BQS0 Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Brush Border Membrane Phosphatase Binding Brush Border PDZ Domain Binding Cellular Localization Apical Part Of Cell Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Beta-catenin Binding Intracellular Protein Localization Susceptibility To T Cell Mediated Cytotoxicity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Susceptibility To Natural Killer Cell Mediated Cytotoxicity Scavenger Receptor Binding Molecular Adaptor Activity Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Endomembrane System Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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