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SLC22A4
Gene Name
solute carrier family 22 (organic cation/zwitterion transporter), member 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrion
Plasma Membrane
Integral Component Of Plasma Membrane
Apical Plasma Membrane
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Secondary Active Organic Cation Transmembrane Transporter Activity
Carnitine Transmembrane Transporter Activity
Symporter Activity
Cation:cation Antiporter Activity
Quaternary Ammonium Group Transmembrane Transporter Activity
PDZ Domain Binding
Biological Process
Triglyceride Metabolic Process
Sodium Ion Transport
Body Fluid Secretion
Carnitine Metabolic Process
Organic Cation Transport
Quaternary Ammonium Group Transport
Carnitine Transport
Transmembrane Transport
Carnitine Transmembrane Transport
Pathways
Organic cation transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Drugs
L-Carnitine
Diseases
GWAS
Crohn's disease (
22412388
21102463
)
Fibrinogen (
20031577
)
Inflammatory bowel disease (
23128233
)
Metabolic traits (
21886157
)
Protein-protein Interactions
4 interactors:
PDZD3
PDZK1
SLC9A3R1
SLC9A3R2
Entrez ID
6583
HPRD ID
09171
Ensembl ID
ENSG00000197208
Uniprot IDs
Q9H015
PDB IDs
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of CGMP Biosynthetic Process
Renal Phosphate Ion Absorption
Negative Regulation Of Guanylate Cyclase Activity
Monocarboxylic Acid Transport
Glutathione Transport
Negative Regulation Of Sodium:proton Antiporter Activity
Renal Sodium Ion Transport
Cellular Phosphate Ion Homeostasis
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Sodium:proton Antiporter Activity
Carboxylic Acid Transport
Organic Acid Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Ion Transport
Bile Acid Secretion
CGMP-mediated Signaling
Receptor Guanylyl Cyclase Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Ion Transmembrane Transport
Oligopeptide Transport
Carnitine Transport
Organic Anion Transport
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Renal Absorption
Regulation Of Proton Transport
Phosphate Ion Homeostasis
Microvillus Assembly
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Microvillus Organization
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Quaternary Ammonium Group Transport
Regulation Of CGMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Regulation Of Ion Transport
Regulation Of Excretion
Monovalent Inorganic Cation Transport
Anion Transport
Regulation Of Sodium Ion Transmembrane Transporter Activity
Cyclic-nucleotide-mediated Signaling
Bile Acid And Bile Salt Transport
Regulation Of CGMP Metabolic Process
Positive Regulation Of Protein Targeting To Membrane
Dopamine Receptor Signaling Pathway
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Nucleotide Metabolic Process
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