SLC22A4

Name	solute carrier family 22 member 4
Structure	No pdb structure
Novel Interactors	1 novel interactors: PVR
Interactors	4 interactors: NHERF1 NHERF2 NHERF4 PDZK1
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Mitochondrial Membrane Neuronal Cell Body
	Molecular Function	Nucleotide Binding Acetylcholine Transmembrane Transporter Activity Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Sulfur Amino Acid Transport Triglyceride Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Lactation Carnitine Metabolic Process Quaternary Ammonium Group Transport Carnitine Transport Response To Lipopolysaccharide Response To Vitamin D Xenobiotic Transport Response To Exogenous DsRNA Acetylcholine Uptake Transmembrane Transport Amino Acid Import Across Plasma Membrane Liver Regeneration Carnitine Transmembrane Transport
Pathways	SLC-mediated transport of organic cations
Drugs	Levocarnitine
Diseases	Crohn's disease
GWAS	Asthma ( 31619474 ) Asthma (sex interaction) ( 24824216 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 22412388 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Fibrinogen ( 20031577 ) Fibrinogen levels ( 26561523 ) Granulocyte count ( 27863252 ) Immature fraction of reticulocytes ( 27863252 ) Inflammatory bowel disease ( 28067908 23128233 ) Intracranial aneurysm ( 33199917 ) Itch intensity from mosquito bite ( 28199695 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 27863252 ) Metabolic traits ( 21886157 ) Monocyte count ( 27863252 ) Myeloid white cell count ( 27863252 ) Myocardial infarction ( 33532862 ) Nasal polyps ( 30643255 ) Neutrophil count ( 27863252 ) Platelet count ( 32888494 ) Serum metabolite levels ( 23093944 33031748 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) White blood cell count ( 27863252 )
Entrez ID	6583
HPRD ID	09171
Ensembl ID	ENSG00000197208
Uniprot IDs	Q9H015
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Brush Border Membrane Phosphatase Binding Brush Border PDZ Domain Binding Cellular Localization Apical Part Of Cell Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Beta-catenin Binding Intracellular Protein Localization Susceptibility To T Cell Mediated Cytotoxicity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Susceptibility To Natural Killer Cell Mediated Cytotoxicity Scavenger Receptor Binding Molecular Adaptor Activity Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Endomembrane System Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport