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SLC22A4 and SLC9A3R1
Number of citations of the paper that reports this interaction (PMID
15553237
)
5
Data Source:
HPRD
(two hybrid)
SLC22A4
SLC9A3R1
Gene Name
solute carrier family 22 (organic cation/zwitterion transporter), member 4
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrion
Plasma Membrane
Integral Component Of Plasma Membrane
Apical Plasma Membrane
Ruffle
Nucleus
Cytoplasm
Centrosome
Plasma Membrane
Microvillus
Endomembrane System
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Filopodium
Brush Border Membrane
Microvillus Membrane
Vesicle
Intracellular Membrane-bounded Organelle
Membrane Raft
Extracellular Vesicular Exosome
Cell Periphery
Sperm Midpiece
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Secondary Active Organic Cation Transmembrane Transporter Activity
Carnitine Transmembrane Transporter Activity
Symporter Activity
Cation:cation Antiporter Activity
Quaternary Ammonium Group Transmembrane Transporter Activity
PDZ Domain Binding
Receptor Binding
Protein Binding
Beta-catenin Binding
Chloride Channel Regulator Activity
Phosphatase Binding
PDZ Domain Binding
Beta-2 Adrenergic Receptor Binding
Protein Complex Binding
Protein Complex Scaffold
Protein Self-association
Dopamine Receptor Binding
Growth Factor Receptor Binding
Biological Process
Triglyceride Metabolic Process
Sodium Ion Transport
Body Fluid Secretion
Carnitine Metabolic Process
Organic Cation Transport
Quaternary Ammonium Group Transport
Carnitine Transport
Transmembrane Transport
Carnitine Transmembrane Transport
Renal Sodium Ion Transport
Protein Complex Assembly
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Wnt Signaling Pathway
Microvillus Assembly
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Cellular Phosphate Ion Homeostasis
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium:proton Antiporter Activity
Bile Acid Secretion
Cellular Protein Localization
Glutathione Transport
Regulation Of Excretion
Regulation Of Protein Kinase Activity
Negative Regulation Of Protein Kinase B Signaling
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Renal Absorption
Negative Regulation Of ERK1 And ERK2 Cascade
Renal Phosphate Ion Absorption
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Organic cation transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Drugs
L-Carnitine
Diseases
GWAS
Crohn's disease (
22412388
21102463
)
Fibrinogen (
20031577
)
Inflammatory bowel disease (
23128233
)
Metabolic traits (
21886157
)
Fibrinogen (
20031577
)
Protein-Protein Interactions
4 interactors:
PDZD3
PDZK1
SLC9A3R1
SLC9A3R2
52 interactors:
ABCC2
ABCC4
ADRB2
AKAP10
ATP6V1B1
ATP6V1E1
BCL10
CFTR
CLCN3
CNGA2
CTNNB1
EGFR
EZR
GNA11
GNAQ
GRK6
KCNJ1
LHCGR
LPAR2
MSN
NF2
NOS2
OPRK1
P2RY1
PAG1
PDGFRA
PDGFRB
PDZK1
PIK3CA
PLCB1
PLCB2
PTEN
PTH1R
RDX
RLBP1
SCN4A
SLC22A11
SLC22A4
SLC22A5
SLC22A9
SLC26A3
SLC34A1
SLC4A8
SLC9A3
SLCO1A2
SLCO3A1
TBC1D10A
TRPC4
TRPC5
YAP1
YES1
ZNF468
Entrez ID
6583
9368
HPRD ID
09171
05406
Ensembl ID
ENSG00000197208
ENSG00000109062
Uniprot IDs
Q9H015
O14745
PDB IDs
1G9O
1GQ4
1GQ5
1I92
1SGH
2D10
2JXO
2KJD
2KRG
2M0T
2M0U
2M0V
2OZF
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of CGMP Biosynthetic Process
Renal Phosphate Ion Absorption
Negative Regulation Of Guanylate Cyclase Activity
Monocarboxylic Acid Transport
Glutathione Transport
Negative Regulation Of Sodium:proton Antiporter Activity
Renal Sodium Ion Transport
Cellular Phosphate Ion Homeostasis
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Sodium:proton Antiporter Activity
Carboxylic Acid Transport
Organic Acid Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Ion Transport
Bile Acid Secretion
CGMP-mediated Signaling
Receptor Guanylyl Cyclase Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Ion Transmembrane Transport
Oligopeptide Transport
Carnitine Transport
Organic Anion Transport
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Renal Absorption
Regulation Of Proton Transport
Phosphate Ion Homeostasis
Microvillus Assembly
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Microvillus Organization
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Quaternary Ammonium Group Transport
Regulation Of CGMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Regulation Of Ion Transport
Regulation Of Excretion
Monovalent Inorganic Cation Transport
Anion Transport
Regulation Of Sodium Ion Transmembrane Transporter Activity
Cyclic-nucleotide-mediated Signaling
Bile Acid And Bile Salt Transport
Regulation Of CGMP Metabolic Process
Positive Regulation Of Protein Targeting To Membrane
Dopamine Receptor Signaling Pathway
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Nucleotide Metabolic Process
Ion Homeostasis
Ion Transmembrane Transport
Transmembrane Transport
Homeostatic Process
Ion Transport
Anion Transport
Organic Anion Transport
Anion Transmembrane Transport
Chemical Homeostasis
Cellular Ion Homeostasis
Positive Regulation Of Phospholipase C Activity
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of PH
Response To Organonitrogen Compound
Cellular Chemical Homeostasis
Monocarboxylic Acid Transport
Positive Regulation Of Phospholipase Activity
Transport
Cellular Cation Homeostasis
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Regulation Of Vasodilation
Regulation Of Phosphorus Metabolic Process
Cellular Response To Organonitrogen Compound
Response To Stimulus
Inorganic Anion Transport
Regulation Of Ion Transport
Regulation Of Membrane Potential
Cell Development
Response To External Stimulus
Monovalent Inorganic Cation Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Metal Ion Transport
Cellular Homeostasis
Establishment Of Endothelial Barrier
Regulation Of Ion Transmembrane Transport
Blood Coagulation
Response To Estrogen
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Hemostasis
Regulation Of Body Fluid Levels
Signaling
Wound Healing
Response To Organic Substance
Response To Hormone
Cell Surface Receptor Signaling Pathway
Cell Communication
Cation Transport
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Tagcloud
?
adipogenic
alters
amscs
chondrogenic
commitment
deacetylases
destabilizes
foxo1
grown
hdac
hdac1
hdac11
hydroxamic
hyper
interferes
lysate
manipulation
mechanistically
mesenchymal
multipotency
multipotent
nherf1
osteogenic
perturbation
pluripotent
saha
sirt7
suberoylanilide
uncommitted
Tagcloud (Difference)
?
adipogenic
alters
amscs
chondrogenic
commitment
deacetylases
destabilizes
foxo1
grown
hdac
hdac1
hdac11
hydroxamic
hyper
interferes
lysate
manipulation
mechanistically
mesenchymal
multipotency
multipotent
nherf1
osteogenic
perturbation
pluripotent
saha
sirt7
suberoylanilide
uncommitted
Tagcloud (Intersection)
?