NHEJ1 and LIG4

Number of citations of the paper that reports this interaction (PubMedID 16439205)
0

Data Source:
HPRD (in vivo, in vitro)

		NHEJ1	LIG4
Description		non-homologous end joining factor 1	DNA ligase 4
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Chromosome DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding DNA End Binding DNA Polymerase Binding	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization
Pathways		Nonhomologous End-Joining (NHEJ)	2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation; NHEJ1 syndrome	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Appendicular lean mass ( 33097823) Height ( 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Thyroid stimulating hormone levels ( 32769997) Waist circumference adjusted for body mass index ( 34021172)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)
Interacting Genes		3 interacting genes: ATM LIG4 XRCC4	103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		79840	3981
HPRD ID		07784	03500
Ensembl ID		ENSG00000187736	ENSG00000174405
Uniprot IDs		H7C0G7 Q9H9Q4	A0A0C4DGV9 A8K8Q4 P49917
PDB IDs		2QM4 2R9A 3Q4F 3RWR 3SR2 3W03 6ERG 6ERH 7LSY 7LT3 7NFC 7NFE 7ZYG 8BHV 8BHY 8BOT 8EZA 8EZB	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		V(D)J Recombination Response To X-ray Somatic Cell DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining DNA Ligase IV Complex Response To Ionizing Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Double-strand Break Repair Cellular Response To Lithium Ion DNA Recombination Response To Lithium Ion Protein Localization To Site Of Double-strand Break Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Response To Radiation Somatic Diversification Of Immunoglobulins DNA Repair Response To Gamma Radiation Cellular Response To Ionizing Radiation DNA Metabolic Process DNA Damage Response Site Of Double-strand Break Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Neuron Apoptotic Process Ligase Activity Establishment Of Integrated Proviral Latency FHA Domain Binding Positive Regulation Of Cellular Component Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Cellular Response To Radiation Chromosome, Telomeric Region Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cellular Response To Metal Ion Establishment Of Viral Latency Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity DNA Ligase (ATP) Activity DNA Ligase Activity Regulation Of Chromosome Organization Regulation Of Neuron Apoptotic Process Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination	Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination
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