NHEJ1 and XRCC4

Number of citations of the paper that reports this interaction (PMID 17567543)
19

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		NHEJ1	XRCC4
Gene Name		nonhomologous end-joining factor 1	X-ray repair complementing defective repair in Chinese hamster cells 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nonhomologous End Joining Complex	Condensed Chromosome Nucleus Nucleoplasm Centrosome Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Ligase Activity	In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency
Pathways			HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS			Hypertension ( 21626137)
Protein-Protein Interactions		2 interactors: LIG4 XRCC4	19 interactors: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM
Entrez ID		79840	7518
HPRD ID		07784	15951
Ensembl ID		ENSG00000187736	ENSG00000152422
Uniprot IDs		Q9H9Q4	Q13426 Q7Z763
PDB IDs		2QM4 2R9A 3Q4F 3RWR 3SR2 3W03	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03
Enriched GO Terms of Interacting Partners?		Pro-B Cell Differentiation Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Lymphoid Progenitor Cell Differentiation DNA Ligation Cellular Response To Lithium Ion Double-strand Break Repair Via Nonhomologous End Joining Isotype Switching V(D)J Recombination Response To Lithium Ion Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Response To Gamma Radiation Immunoglobulin Production Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Regulation Of Fibroblast Proliferation Cellular Response To Metal Ion Cellular Response To Inorganic Substance Response To Ionizing Radiation Double-strand Break Repair Hematopoietic Progenitor Cell Differentiation T Cell Differentiation Leukocyte Activation Involved In Immune Response B Cell Activation Negative Regulation Of Neuron Apoptotic Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Negative Regulation Of Neuron Death DNA Ligation Involved In DNA Recombination DNA Recombination Lymphocyte Differentiation Regulation Of Neuron Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of Neuron Death Leukocyte Cell-cell Adhesion Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation	Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Polynucleotide 3' Dephosphorylation Single Strand Break Repair Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Apoptotic Process Programmed Cell Death Cellular Response To Stress B Cell Activation Cell Death Death Pro-B Cell Differentiation Cell Activation Immunoglobulin Production Response To Radiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination DNA Recombination Lymphoid Progenitor Cell Differentiation Response To Stress DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Autophosphorylation Regulation Of Voltage-gated Calcium Channel Activity DNA Catabolic Process Response To Ionizing Radiation Isotype Switching Lymphocyte Activation T Cell Differentiation V(D)J Recombination Mitotic Cell Cycle Checkpoint Regulation Of Protein Autophosphorylation Cellular Response To Stimulus Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Central Nervous System Development Response To Stimulus Regulation Of Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?