NHEJ1

Description		non-homologous end joining factor 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Chromosome DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding DNA End Binding DNA Polymerase Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation; NHEJ1 syndrome
GWAS		Appendicular lean mass ( 33097823) Height ( 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Thyroid stimulating hormone levels ( 32769997) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: ATM LIG4 XRCC4
Entrez ID		79840
HPRD ID		07784
Ensembl ID		ENSG00000187736
Uniprot IDs		H7C0G7 Q9H9Q4
PDB IDs		2QM4 2R9A 3Q4F 3RWR 3SR2 3W03 6ERG 6ERH 7LSY 7LT3 7NFC 7NFE 7ZYG 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		V(D)J Recombination Response To X-ray Somatic Cell DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining DNA Ligase IV Complex Response To Ionizing Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Double-strand Break Repair Cellular Response To Lithium Ion DNA Recombination Response To Lithium Ion Protein Localization To Site Of Double-strand Break Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Response To Radiation Somatic Diversification Of Immunoglobulins DNA Repair Response To Gamma Radiation Cellular Response To Ionizing Radiation DNA Metabolic Process DNA Damage Response Site Of Double-strand Break Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Neuron Apoptotic Process Ligase Activity Establishment Of Integrated Proviral Latency FHA Domain Binding Positive Regulation Of Cellular Component Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Cellular Response To Radiation Chromosome, Telomeric Region Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cellular Response To Metal Ion Establishment Of Viral Latency Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity DNA Ligase (ATP) Activity DNA Ligase Activity Regulation Of Chromosome Organization Regulation Of Neuron Apoptotic Process Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination
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