ZC2HC1C and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZC2HC1C	PRKAB2
Description		zinc finger C2HC-type containing 1C	protein kinase AMP-activated non-catalytic subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process		Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Positive Regulation Of Cold-induced Thermogenesis
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Neurociticism ( 29500382) Refractive error ( 32231278)
Interacting Genes		80 interacting genes: ACTMAP ACTN2 ANKS1A ARMC7 BANP BICD2 BYSL CABP5 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC85B CCDC88B CIB3 CLIC3 CRACR2A DDX6 EMILIN1 ENKD1 FAM90A1 FBXO7 FGFR1OP2 FSD2 GFAP GOLGA1 GOLGA2 GOLGA6A GPRASP2 HOOK2 HSF2BP KASH5 KAT5 KATNBL1 KIF9 KRT15 KRT20 KRT40 LMNA LMNB2 LZTS2 MAPK9 MAPRE3 MID2 MTUS2 NCKIPSD NDEL1 NDOR1 NEK6 NOXA1 NTAQ1 OSGIN1 PFDN5 PIBF1 PNMA1 POLR1C PRKAB2 PSTPIP1 RABGEF1 RAD51D RINT1 SFN SIKE1 SMARCD1 SORBS3 SPAG5 TFIP11 TNPO2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM55 TRIM63 UBASH3A VPS52 ZNF655 ZNF76	172 interacting genes: ABHD11 ACTMAP ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BLZF1 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFAP68 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GPRASP3 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRABD4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PPP1R3B PPP1R3C PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		79696	5565
HPRD ID		16607	04117
Ensembl ID		ENSG00000119703	ENSG00000131791
Uniprot IDs		J3KMY6 Q53FD0	O43741 X5D2Z8
PDB IDs			2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Cytoplasm Microtubule Cytoskeleton Organization Protein Binding Microtubule Microtubule-based Process Microtubule Binding Organelle Organization Identical Protein Binding Microtubule Organizing Center Intracellular Transport Structural Constituent Of Cytoskeleton Cytosol Intermediate Filament Centrosome Spindle Localization Establishment Of Localization In Cell Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Establishment Of Organelle Localization Membraneless Organelle Assembly Cellular Localization Organelle Localization Establishment Of Spindle Orientation Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Spindle Assembly Protein Localization To Cytoskeleton Supramolecular Fiber Organization Spindle Pole Spindle Organization Intracellular Protein Localization Establishment Of Spindle Localization Positive Regulation Of Autophagy Nuclear Pore Localization Dynein Light Intermediate Chain Binding Regulation Of Autophagy Microtubule Nucleation Intermediate Filament Organization Chromosome Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole Thioesterase Binding Establishment Of Mitotic Spindle Localization Regulation Of Organelle Organization Golgi Cis Cisterna	Keratin Filament Intermediate Filament Protein Binding Identical Protein Binding AMP-activated Protein Kinase Activity Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway P53 Binding Glycogen Binding Nucleotide-activated Protein Kinase Complex
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