ZC2HC1C and RABGEF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ZC2HC1C	RABGEF1
Gene Name		zinc finger, C2HC-type containing 1C	RAB guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Early Endosome Vesicle Recycling Endosome
	Molecular Function	Metal Ion Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process		Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		23 interactors: BANP CALCOCO2 CCDC136 CCDC85B EMILIN1 FSD2 GFAP HOOK2 KRT15 KRT20 KRT40 MID2 MTUS2 PNMA1 RABGEF1 SFN SPAG5 SPERT TFIP11 TRAF1 TRAF2 TRIM23 TRIM27	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		79696	27342
HPRD ID		16607	11477
Ensembl ID		ENSG00000119703	ENSG00000243335
Uniprot IDs		Q53FD0	B4DZM7 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Intermediate Filament Organization Regulation Of Protein Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Establishment Of Protein Localization Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Protein Secretion Protein K63-linked Ubiquitination Protein Trimerization Negative Regulation Of Cytokine Secretion Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Kit Signaling Pathway Spliceosomal Complex Disassembly Positive Regulation Of Schwann Cell Proliferation Regulation Of Secretion Regulation Of Viral Transcription Negative Regulation Of Viral Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Protein Phosphorylation Response To Stress Immune Response Regulation Of Cellular Component Organization Regulation Of Epidermal Cell Division Defense Response Negative Regulation Of Protein Secretion Innate Immune Response Negative Regulation Of Phosphorylation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Immune Response Negative Regulation Of Calcium Ion Import Bergmann Glial Cell Differentiation Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Cytokine Secretion Apoptotic Process Negative Regulation Of Glial Cell Apoptotic Process Organelle Organization Protein Localization To Microtubule Programmed Cell Death Regulation Of Viral Process	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?