ZC2HC1C and CRACR2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZC2HC1C	CRACR2A
Description		zinc finger C2HC-type containing 1C	calcium release activated channel regulator 2A
Image		No pdb structure
GO Annotations	Cellular Component		Golgi Membrane Immunological Synapse Extracellular Region Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytoskeleton Plasma Membrane Membrane Vesicle Trans-Golgi Network Membrane Weibel-Palade Body Specific Granule Lumen Specific Granule
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process		Store-operated Calcium Entry Adaptive Immune Response Immune System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Protein Localization Vesicle-mediated Transport Endosomal Transport Activation Of Store-operated Calcium Channel Activity Response To Histamine T-helper 1 Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Calcium Ion Transport
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Neurociticism ( 29500382) Refractive error ( 32231278)	Femur bone mineral density x serum urate levels interaction ( 34046847) Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		80 interacting genes: ACTMAP ACTN2 ANKS1A ARMC7 BANP BICD2 BYSL CABP5 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC85B CCDC88B CIB3 CLIC3 CRACR2A DDX6 EMILIN1 ENKD1 FAM90A1 FBXO7 FGFR1OP2 FSD2 GFAP GOLGA1 GOLGA2 GOLGA6A GPRASP2 HOOK2 HSF2BP KASH5 KAT5 KATNBL1 KIF9 KRT15 KRT20 KRT40 LMNA LMNB2 LZTS2 MAPK9 MAPRE3 MID2 MTUS2 NCKIPSD NDEL1 NDOR1 NEK6 NOXA1 NTAQ1 OSGIN1 PFDN5 PIBF1 PNMA1 POLR1C PRKAB2 PSTPIP1 RABGEF1 RAD51D RINT1 SFN SIKE1 SMARCD1 SORBS3 SPAG5 TFIP11 TNPO2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM55 TRIM63 UBASH3A VPS52 ZNF655 ZNF76	35 interacting genes: ANKRD29 ASB3 ATN1 CCHCR1 CDC23 DDIT3 FAM156A FAM156B FAM86C1P FKBP6 GIGYF1 GOLGA2 KRT31 KRT75 KRTAP13-1 KRTAP19-5 LRIF1 MDFI MID2 MKRN3 NOTCH2NLA OIP5 PNMA5 POLR1C RBAK RORB SLAIN1 SORBS3 TLE5 TRAF1 TRIM29 USP2 ZC2HC1C ZNF20 ZNF655
Entrez ID		79696	84766
HPRD ID		16607	10079
Ensembl ID		ENSG00000119703	ENSG00000130038
Uniprot IDs		J3KMY6 Q53FD0	Q9BSW2
PDB IDs			6PSD
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Cytoplasm Microtubule Cytoskeleton Organization Protein Binding Microtubule Microtubule-based Process Microtubule Binding Organelle Organization Identical Protein Binding Microtubule Organizing Center Intracellular Transport Structural Constituent Of Cytoskeleton Cytosol Intermediate Filament Centrosome Spindle Localization Establishment Of Localization In Cell Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Establishment Of Organelle Localization Membraneless Organelle Assembly Cellular Localization Organelle Localization Establishment Of Spindle Orientation Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Spindle Assembly Protein Localization To Cytoskeleton Supramolecular Fiber Organization Spindle Pole Spindle Organization Intracellular Protein Localization Establishment Of Spindle Localization Positive Regulation Of Autophagy Nuclear Pore Localization Dynein Light Intermediate Chain Binding Regulation Of Autophagy Microtubule Nucleation Intermediate Filament Organization Chromosome Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole Thioesterase Binding Establishment Of Mitotic Spindle Localization Regulation Of Organelle Organization Golgi Cis Cisterna	Identical Protein Binding
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