DDR1 and MAPK6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DDR1	MAPK6
Gene Name		discoidin domain receptor tyrosine kinase 1	mitogen-activated protein kinase 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Embryo Implantation Lactation Negative Regulation Of Cell Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways		Non-integrin membrane-ECM interactions
Drugs		Imatinib
Diseases
GWAS		Age-related macular degeneration ( 23455636) HIV-1 control ( 20041166) Ulcerative colitis ( 20848476)
Protein-Protein Interactions		17 interactors: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		780	5597
HPRD ID		02678	04213
Ensembl ID		ENSG00000204580	ENSG00000069956
Uniprot IDs		Q08345 Q96T61 Q96T62	Q16659
PDB IDs		3ZOS 4AG4 4BKI 4BKJ	2I6L
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Fibril Organization Collagen Catabolic Process Axon Guidance Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuron Projection Development Cell Development Heart Development Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Generation Of Neurons Extracellular Matrix Organization Extracellular Structure Organization Fibroblast Growth Factor Receptor Signaling Pathway Neuron Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Anatomical Structure Morphogenesis Regulation Of Kinase Activity Locomotion Response To External Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Projection Morphogenesis Cell Differentiation Neurotrophin Signaling Pathway Cardiovascular System Development Cell Part Morphogenesis Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Skeletal System Development Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Sensory Organ Development Regulation Of MAP Kinase Activity	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?