DDR1 and SNRNP40

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DDR1	SNRNP40
Gene Name		discoidin domain receptor tyrosine kinase 1	small nuclear ribonucleoprotein 40kDa (U5)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Nucleoplasm U5 SnRNP Small Nucleolar Ribonucleoprotein Complex Cytoplasm Catalytic Step 2 Spliceosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Embryo Implantation Lactation Negative Regulation Of Cell Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression
Pathways		Non-integrin membrane-ECM interactions	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs		Imatinib
Diseases
GWAS		Age-related macular degeneration ( 23455636) HIV-1 control ( 20041166) Ulcerative colitis ( 20848476)	Alcohol dependence ( 23455491)
Protein-Protein Interactions		17 interactors: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR	6 interactors: ACP5 APP DDR1 DHX16 EFTUD2 SNRNP200
Entrez ID		780	9410
HPRD ID		02678	08481
Ensembl ID		ENSG00000204580	ENSG00000060688
Uniprot IDs		Q08345 Q96T61 Q96T62	A0MNP2 B4DQJ1 Q96DI7
PDB IDs		3ZOS 4AG4 4BKI 4BKJ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Fibril Organization Collagen Catabolic Process Axon Guidance Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuron Projection Development Cell Development Heart Development Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Generation Of Neurons Extracellular Matrix Organization Extracellular Structure Organization Fibroblast Growth Factor Receptor Signaling Pathway Neuron Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Anatomical Structure Morphogenesis Regulation Of Kinase Activity Locomotion Response To External Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Projection Morphogenesis Cell Differentiation Neurotrophin Signaling Pathway Cardiovascular System Development Cell Part Morphogenesis Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Skeletal System Development Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Sensory Organ Development Regulation Of MAP Kinase Activity	MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Smooth Muscle Cell-matrix Adhesion Cis Assembly Of Pre-catalytic Spliceosome Negative Regulation Of Superoxide Anion Generation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Riboflavin Metabolic Process Axon Choice Point Recognition Heterocycle Metabolic Process Collagen-activated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Regulation Of Superoxide Anion Generation Negative Regulation Of Interleukin-1 Beta Production Nitrogen Compound Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization RNA Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process MRNA Cis Splicing, Via Spliceosome Cellular Copper Ion Homeostasis Negative Regulation Of Interleukin-12 Production Wound Healing, Spreading Of Cells Regulation Of Extracellular Matrix Organization Gene Expression Muscle Cell Migration Copper Ion Homeostasis Suckling Behavior Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mammary Gland Lobule Development Mammary Gland Alveolus Development Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Branching Involved In Mammary Gland Duct Morphogenesis
Tagcloud ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts
Tagcloud (Difference) ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts
Tagcloud (Intersection) ?