DDR1 and SNRNP40

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		DDR1	SNRNP40
Name		discoidin domain receptor tyrosine kinase 1	small nuclear ribonucleoprotein U5 subunit 40
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Sno(s)RNA-containing Ribonucleoprotein Complex Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing
Pathways		Non-integrin membrane-ECM interactions	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		Imatinib Fostamatinib Pralsetinib	None
GWAS		Age-related macular degeneration ( 23455636 ) Arterial stiffness index ( 31235810 ) Autism spectrum disorder or schizophrenia ( 28540026 ) HIV-1 control ( 20041166 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Malaria ( 31844061 ) Microalbuminuria in type 1 diabetes ( 31537649 ) Response to hepatitis B vaccine ( 29534301 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Schizophrenia ( 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Takayasu arteritis ( 25604533 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 20848476 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Alcohol dependence ( 23455491 ) Body mass index ( 26426971 29615537 )
Novel Interactors		1 novel interactors: BRD2	None recorded
Interacting Genes		20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2	6 interacting genes: ACP5 APP CEBPA DDR1 EIF4ENIF1 NOL8
Entrez ID		780	9410
HPRD ID		02678	08481
Ensembl ID		ENSG00000204580	ENSG00000060688
Uniprot IDs		A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62	A0MNP2 Q96DI7
PDB IDs		3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9	3JCR 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6ZYM 7ABG 7ABI 7DVQ 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD
GO Terms Enriched among Interactors		Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction	Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Response To Peptide Regulation Of Nitric Oxide Metabolic Process Response To Cytokine Regulation Of Inflammatory Response Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Regulation Of Interleukin-1 Beta Production Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Memory Notch Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Kinase Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Reactive Oxygen Species Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Cell Maturation Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Cell Population Proliferation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response