DDR1 and BEND5

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		DDR1	BEND5
Name		discoidin domain receptor tyrosine kinase 1	BEN domain containing 5
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Golgi Apparatus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension	Negative Regulation Of DNA-templated Transcription
Pathways		Non-integrin membrane-ECM interactions	None
Drugs		Imatinib Fostamatinib Pralsetinib	None
GWAS		Age-related macular degeneration ( 23455636 ) Arterial stiffness index ( 31235810 ) Autism spectrum disorder or schizophrenia ( 28540026 ) HIV-1 control ( 20041166 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Malaria ( 31844061 ) Microalbuminuria in type 1 diabetes ( 31537649 ) Response to hepatitis B vaccine ( 29534301 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Schizophrenia ( 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Takayasu arteritis ( 25604533 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 20848476 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2	31 interacting genes: APP BUD31 CFTR CTNNBIP1 DDR1 EIF3D ERBB3 FAM161A FXR1 GFI1B GORASP2 GRAP2 HOXA1 LCE1B LMO3 NTAQ1 PIMREG PRKAB2 PTGR2 RTP5 SMARCD1 TSC1 TSPOAP1 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417 ZNF688
Entrez ID		780	79656
HPRD ID		02678	07756
Ensembl ID		ENSG00000204580	ENSG00000162373
Uniprot IDs		A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62	A0A0S2Z5N0 Q7L4P6
PDB IDs		3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9	Not available
GO Terms Enriched among Interactors		Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction	Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Long-term Synaptic Potentiation Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity