DDR1 and COL11A1

Number of citations of the paper that reports this interaction (PubMedID 9659900)
0

Data Source:
HPRD (in vivo)

		DDR1	COL11A1
Description		discoidin domain receptor tyrosine kinase 1	collagen type XI alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension	Cartilage Condensation Chondrocyte Development Heart Morphogenesis Proteoglycan Metabolic Process Visual Perception Sensory Perception Of Sound Collagen Fibril Organization Endodermal Cell Differentiation Tendon Development Inner Ear Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cartilage Development Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		Non-integrin membrane-ECM interactions	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs		Imatinib Fostamatinib Pralsetinib
Diseases			Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carpal tunnel syndrome ( 30833571) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Femoral neck bone mineral density ( 22504420) Glaucoma (primary angle closure) ( 27064256 22922875) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Height ( 28552196) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intertrochanteric region size ( 31053729) Lateral ventricle temporal horn volume ( 31530798) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Protein quantitative trait loci ( 18464913) Spine bone size ( 31053729) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Tinnitus ( 32970095) Triglyceride levels x loop diuretics use interaction ( 31806883) Trochanter size ( 31053729) Urate levels (BMI interaction) ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2	6 interacting genes: APP DDR1 ITGAV SPARC TGM2 THBS1
Entrez ID		780	1301
HPRD ID		02678	00375
Ensembl ID		ENSG00000204580	ENSG00000060718
Uniprot IDs		A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62	P12107 Q59HB5
PDB IDs		3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction	Platelet Alpha Granule Extracellular Matrix Binding Platelet Alpha Granule Lumen Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Binding Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Cellular Response To Catecholamine Stimulus Positive Regulation Of Locomotion Response To Catecholamine Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Cell Surface Apoptotic Cell Clearance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Fibronectin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tube Morphogenesis Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Regulation Of Angiogenesis Extracellular Exosome Regulation Of Cell Migration Extracellular Region Regulation Of Vasculature Development Negative Regulation Of Endothelial Cell Proliferation External Side Of Plasma Membrane Regulation Of Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Collagen Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?