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YWHAB and GEM
Number of citations of the paper that reports this interaction (PubMedID
14701738
)
32
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
YWHAB
GEM
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
GTP binding protein overexpressed in skeletal muscle
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Midbody
Spindle Midzone
Mitotic Spindle
Molecular Function
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Nucleotide Binding
Magnesium Ion Binding
GTPase Activity
Calcium Channel Regulator Activity
Protein Binding
Calmodulin Binding
GTP Binding
GDP Binding
Biological Process
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chromosome Organization
Metaphase Chromosome Alignment
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
NPAS4 regulates expression of target genes
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Carotid plaque burden (
28282560
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
128 interacting genes:
A2M
AHCYL1
ANKRD36B
APOH
ASB15
BEGAIN
BLOC1S2
BLZF1
BMP1
CACNB3
CALM1
CARD9
CCDC102B
CCDC125
CCDC88B
CDR2
CEP70
CLDN15
CLEC4G
COG6
COG8
CTSL
CYSRT1
DBF4B
DEUP1
DISC1
DRC4
ECSIT
EFHC2
EXOSC8
FSAF1
GADD45GIP1
GMIP
GOLGA2
GOLGA6L9
GOPC
GPRASP3
HOOK2
HSF2BP
IHO1
IKZF3
INCA1
INO80E
INSC
ISCA2
KATNBL1
KCTD9
KIFC3
KLC3
KRT31
KRT34
KRT36
KRT40
KRT6A
KRT83
KRTAP10-3
KRTAP10-7
KRTAP10-8
LIMS1
LRP2BP
LZTS2
MCRS1
MESD
MGLL
MID2
MIPOL1
MKRN3
MORN3
MSS51
MTUS2
MYOG
NDUFAF3
NDUFB7
NDUFS8
NOTCH2NLA
OIP5
PBX4
PDLIM7
PIH1D1
PLAGL2
PLEKHF2
PNMA1
POF1B
PRDM14
PRDM6
RNF7
RUNDC3A
SDHB
SNAP91
SORBS3
SPAG5
SPATA6
SSX2IP
TBC1D3B
TBC1D3G
TCF4
TFIP11
TGM7
TLE5
TP53BP2
TRAF1
TRAF2
TRIM10
TRIM23
TRIM27
TRIM32
TRIM54
TRIM69
USH1G
USHBP1
VIM
VPS28
VPS52
VTN
WWOX
YBEY
YPEL3
YWHAB
ZBTB42
ZC4H2
ZMAT5
ZNF20
ZNF552
ZNF655
ZNF688
ZNF774
ZRANB1
ZSCAN9
Entrez ID
7529
2669
HPRD ID
03184
11553
Ensembl ID
ENSG00000166913
ENSG00000164949
Uniprot IDs
P31946
V9HWD6
P55040
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
2CJW
2G3Y
2HT6
Enriched GO Terms of Interacting Partners
?
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
Identical Protein Binding
Protein Binding
Keratin Filament
Intermediate Filament
Cytoskeleton
Intermediate Filament Organization
Microtubule Binding
Structural Constituent Of Skin Epidermis
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Microtubule
Cytoskeleton Organization
Zinc Ion Binding
Organelle Organization
TORC1 Complex Assembly
Centrosome
Negative Regulation Of Viral Transcription
Suppression Of Viral Release By Host
Microtubule-based Process
Supramolecular Fiber Organization
Ubiquitin Protein Ligase Activity
Regulation Of Viral Transcription
Protein Localization To Cytoskeleton
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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