YWHAB and ERRFI1

Number of citations of the paper that reports this interaction (PubMedID 20351267)
44

Data Source:
BioGRID (two hybrid)

		YWHAB	ERRFI1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	ERBB receptor feedback inhibitor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Vacuole Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Protein-containing Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity	GTPase Activator Activity Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Protein Targeting Signal Transduction Intracellular Protein Localization Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Skeletal System Development Liver Development Tissue Homeostasis Glucose Metabolic Process Lipid Metabolic Process Bile Acid Biosynthetic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Embryo Implantation Cholesterol Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cell Migration Negative Regulation Of Protein Autophosphorylation Response To Estradiol Response To Progesterone Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Uterine Epithelium Development Chondrocyte Proliferation Limb Joint Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cholesterol Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Response To Steroid Hormone Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Cartilage Development Uterus Development Lung Vasculature Development Lung Epithelium Development Epithelium Development Fat Pad Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)	Crohn's disease ( 28067908) Hair shape ( 29220522) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		147 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FILNC1 FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B NCAM2 NEDD4L OSBPL3 PARD3 PARD6B PDCL2 PDE3B PDE4B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RIPK2 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1	58 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 GAS1 GNPDA2 GTF2H2 HYDIN IL2RG MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SKIC8 SLC61A1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WEE1 YWHAB ZPBP
Entrez ID		7529	54206
HPRD ID		03184	09218
Ensembl ID		ENSG00000166913	ENSG00000116285
Uniprot IDs		P31946 V9HWD6	B3KTV8 I6S2Y9 Q9UJM3
PDB IDs		2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP 8DP5 8EQ8 8EQH	2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cytosol Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm Protein Phosphorylation ATP Binding Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Signal Transduction Cellular Response To Oxygen-containing Compound Protein Tyrosine Kinase Activity Response To Stress Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Membrane Potential Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Cadherin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Regulation Of Biological Quality Plasma Membrane Response To Insulin Positive Regulation Of Catabolic Process Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Phosphorylation	Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Enzyme Binding ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Protein Phosphorylation Phosphoserine Residue Binding Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Phosphorylation Protein Kinase Activity ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Ruffle Membrane Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Animal Organ Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Estradiol Endothelin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Receptor Complex Response To Epidermal Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Progesterone Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cis-Golgi Network Membrane Cell Cycle G2/M Phase Transition DNA Repair Complex
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