GEM and SDHB

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		GEM	SDHB
Gene Name		GTP binding protein overexpressed in skeletal muscle	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Protein Binding Succinate Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Ubiquinone Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Immune Response Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Chromosome Organization Metaphase Plate Congression	Tricarboxylic Acid Cycle Succinate Metabolic Process Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS			Height ( 20189936)
Protein-Protein Interactions		40 interactors: A2M AHCYL1 APOH BLZF1 BMP1 CCDC102B CCDC67 CLDN15 CLEC4G COG8 CTSL GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NL PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB	5 interactors: ABCA1 GEM PIK3R5 SPRY2 XRN1
Entrez ID		2669	6390
HPRD ID		11553	01707
Ensembl ID		ENSG00000164949	ENSG00000117118
Uniprot IDs		P55040	P21912
PDB IDs		2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex I Biogenesis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Protein Complex Assembly Mitochondrial Respiratory Chain Complex Assembly Regulation Of Complement Activation Intracellular Transport Regulation Of Protein Binding Spliceosomal Complex Disassembly Establishment Of Localization In Cell Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization	Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Interleukin-1 Beta Secretion Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nuclear MRNA Surveillance Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Cholesterol Storage Lung Growth High-density Lipoprotein Particle Assembly RNA Surveillance Establishment Of Organelle Localization Intracellular Cholesterol Transport Intracellular Sterol Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Histone MRNA Catabolic Process Phospholipid Homeostasis Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process RRNA Catabolic Process Phospholipid Efflux Phagocytosis, Engulfment Bud Elongation Involved In Lung Branching Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Organelle Localization Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of MAPK Cascade Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Positive Regulation Of Protein Kinase Activity Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Lipid Storage Positive Regulation Of Kinase Activity Negative Regulation Of Ras GTPase Activity Positive Regulation Of Cholesterol Transport Histone MRNA Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cholesterol Efflux Phosphatidylinositol 3-kinase Signaling
Tagcloud ?		annotation centralized clinvar coherent compilation consortium curates curation das elect empowering exome expandable freestanding gbrowse guid https informs interrogation lsdb mseqdr mtdna phenotyping prioritize secure shareholders suite tracks void	alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic
Tagcloud (Difference) ?		annotation centralized clinvar coherent compilation consortium curates curation das elect empowering exome expandable freestanding gbrowse guid https informs interrogation lsdb mseqdr mtdna phenotyping prioritize secure shareholders suite tracks void	alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic
Tagcloud (Intersection) ?