Wiki-Pi
About
Search
People
Updates
Search
YWHAB and CDKN1B
Number of citations of the paper that reports this interaction (PubMedID
15057270
)
58
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
YWHAB
CDKN1B
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
cyclin dependent kinase inhibitor 1B
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Centrosome
Cytosol
Cilium
Cul4A-RING E3 Ubiquitin Ligase Complex
Ciliary Basal Body
Molecular Function
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin-dependent Protein Kinase Regulator Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein-folding Chaperone Binding
Molecular Adaptor Activity
Molecular Function Inhibitor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Placenta Development
Potassium Ion Transport
Apoptotic Process
Regulation Of Exit From Mitosis
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Heart Development
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Programmed Cell Death
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA Replication
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Nuclear Export
Regulation Of Cell Cycle
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Senescence
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Cell Cycle G1/S Phase Transition
Epithelial Cell Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
Prostate cancer
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
31562322
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
33272962
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
70 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RCHY1
RNF123
RNF6
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2L3
UBE3A
UCHL1
WWP1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
7529
1027
HPRD ID
03184
02867
Ensembl ID
ENSG00000166913
ENSG00000111276
Uniprot IDs
P31946
V9HWD6
P46527
Q6I9V6
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
7B5L
7B5M
7B5R
7OR8
7ORG
7ORH
7ORS
7ORT
8BYA
8BYL
8BZO
Enriched GO Terms of Interacting Partners
?
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Modification Process
Nucleus
Cell Cycle Phase Transition
Nucleoplasm
Modification-dependent Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cytosol
Post-translational Protein Modification
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Regulation Of Cell Cycle
Proteolysis
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Cellular Response To Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Catabolic Process
Protein Polyubiquitination
Protein Localization To Nucleus
Transferase Activity
NLS-dependent Protein Nuclear Import Complex
Regulation Of Macromolecule Metabolic Process
Protein Catabolic Process
Regulation Of Metabolic Process
Ubiquitin-protein Transferase Activity
NLS-bearing Protein Import Into Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Proteasomal Protein Catabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Regulation Of DNA Metabolic Process
Protein Import Into Nucleus
Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Ubiquitin Protein Ligase Binding
Protein Kinase Binding
Phosphoserine Residue Binding
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?