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YWHAB and WDR77
Number of citations of the paper that reports this interaction (PubMedID
15324660
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
YWHAB
WDR77
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
WD repeat domain 77
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cul4B-RING E3 Ubiquitin Ligase Complex
Methylosome
Transferase Complex
Molecular Function
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Transcription Coactivator Activity
Protein Binding
Methyl-CpG Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Spliceosomal SnRNP Assembly
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Oocyte Axis Specification
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of MRNA Splicing, Via Spliceosome
Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
snRNP Assembly
RMTs methylate histone arginines
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
46 interacting genes:
AQR
BAG2
CDK19
CDK8
CLNS1A
CREBBP
CTDP1
EIF4A1
GLI1
GPKOW
H2AC21
HNRNPM
LSM3
NKX3-1
PCBP2
PDCD4
PPIL1
PPP1R8
PQBP1
PRKG1
PRKG2
PRMT5
QKI
RBM5
SAP30BP
SF1
SF3A1
SF3B4
SIRT7
SMAD1
SMYD1
SNRPB
SNRPC
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SUZ12
THOC1
TOE1
UBC
YWHAB
YWHAQ
ZMYND19
ZNF207
Entrez ID
7529
79084
HPRD ID
03184
14387
Ensembl ID
ENSG00000166913
ENSG00000116455
Uniprot IDs
P31946
V9HWD6
A0A024R0H7
Q9BQA1
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UGH
6UXX
6UXY
6V0N
6V0O
6V0P
7BO7
7KIB
7KIC
7KID
7L1G
7M05
7MX7
7MXA
7MXC
7MXG
7MXN
7S0U
7S1P
7S1Q
7S1R
7S1S
7SER
7SES
7U30
7UOH
7UY1
7UYF
7ZUP
7ZUQ
7ZUU
7ZUY
7ZV2
7ZVL
7ZVU
8CSG
8CTB
8CYI
8G1U
8VEO
8VET
8VEU
8VEW
8VEX
8VEY
8X6L
9C10
9DOD
9E3A
9E3B
9EYU
9EYV
9EYW
9EYX
9MGL
9MGM
9MGN
9MGP
9MGQ
9MGR
9N3N
9N3O
9N3P
9N3Q
9N3R
Enriched GO Terms of Interacting Partners
?
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Spliceosomal Complex
RNA Splicing
MRNA Processing
MRNA Metabolic Process
Methylosome
RNA Processing
RNA Metabolic Process
Spliceosomal Complex Assembly
PICln-Sm Protein Complex
Catalytic Step 2 Spliceosome
U2-type Prespliceosome Assembly
Spliceosomal SnRNP Assembly
U2 SnRNP
Protein-RNA Complex Assembly
Nucleic Acid Metabolic Process
U2-type Spliceosomal Complex
RNA Binding
7-methylguanosine Cap Hypermethylation
U2-type Catalytic Step 2 Spliceosome
U2-type Precatalytic Spliceosome
Nucleoplasm
U1 SnRNP
Nucleus
U4 SnRNP
U12-type Spliceosomal Complex
Nucleobase-containing Compound Metabolic Process
Small Nuclear Ribonucleoprotein Complex
SMN-Sm Protein Complex
Precatalytic Spliceosome
U5 SnRNP
U4/U6 X U5 Tri-snRNP Complex
Macromolecule Metabolic Process
U7 SnRNP
Ribonucleoprotein Complex
MRNA Binding
Macromolecule Methylation
Methylation
RNA Methylation
Commitment Complex
Protein-containing Complex Assembly
Nucleic Acid Binding
Protein-containing Complex Organization
RNA Modification
CGMP-dependent Protein Kinase Activity
MRNA Cis Splicing, Via Spliceosome
U2-type Prespliceosome
Telomerase Holoenzyme Complex
Histone Pre-mRNA DCP Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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