YWHAB and KIF5B

Number of citations of the paper that reports this interaction (PMID 15324660)
121

Data Source:
HPRD (in vivo)

		YWHAB	KIF5B
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta	kinesin family member 5B
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Microtubule Organizing Center Kinesin Complex Microtubule Membrane Endocytic Vesicle Vesicle Ciliary Rootlet Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Microtubule-based Movement Cytoplasm Organization Axon Guidance Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Cellular Protein Metabolic Process Vesicle Transport Along Microtubule Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1	23 interactors: APC CDC5L DTNB GSK3B KIF5A KLC3 KTN1 NCOA2 NDRG1 PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		7529	3799
HPRD ID		03184	07214
Ensembl ID		ENSG00000166913	ENSG00000170759
Uniprot IDs		P31946	P33176 Q6P164
PDB IDs		2BQ0 2C23 4DNK	1BG2 1MKJ 2P4N 4HNA
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process	Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Protein Transport Establishment Of Protein Localization Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Development Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Apoptotic Process Mast Cell Activation Programmed Cell Death Regulation Of Intracellular Transport Intracellular Signal Transduction Cell Death Cellular Localization Death Regulation Of Apoptotic Process Intracellular Transport Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Transmission Neurogenesis Positive Regulation Of Signal Transduction Histamine Secretion By Mast Cell Signaling Regulation Of Organelle Organization Nervous System Development Cell Communication Transport Regulation Of Cellular Component Organization Synaptic Vesicle Priming Histamine Secretion
Tagcloud ?		3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?