GEM and TRIM10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GEM	TRIM10
Description		GTP binding protein overexpressed in skeletal muscle	tripartite motif containing 10
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle	Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment	Erythrocyte Differentiation Innate Immune Response Host-mediated Suppression Of Symbiont Invasion
Pathways		NPAS4 regulates expression of target genes	Interferon gamma signaling
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) HIV-1 control ( 20041166) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neuroticism ( 29255261) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Tonsillitis ( 30037793)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	19 interacting genes: CDK2 GEM HGS LNX1 PRKAB2 PSMA1 SCNM1 STING1 TRIM35 TRIM44 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 YPEL3 ZNF148 ZNF414 ZNF620
Entrez ID		2669	10107
HPRD ID		11553	05752
Ensembl ID		ENSG00000164949	ENSG00000204613
Uniprot IDs		P55040	A0A1U9X8M5 Q9UDY6
PDB IDs		2CJW 2G3Y 2HT6	7QS0
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton	Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Zinc Ion Binding Positive Regulation Of Defense Response To Virus By Host Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Defense Response To Virus By Host Cyclic-di-GMP Binding STING Complex Protein Modification Process Nucleus Proteolysis Nucleotide Binding Y Chromosome Positive Regulation Of Heterochromatin Formation Transferase Activity Metal Ion Binding Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Regulation Of Defense Response To Virus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Protein K48-linked Ubiquitination 2',3'-cyclic GMP-AMP Binding Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex ESCRT-0 Complex
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