GEM and TBC1D3G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GEM	TBC1D3G
Description		GTP binding protein overexpressed in skeletal muscle	TBC1 domain family member 3G
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle	Endosome Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	GTPase Activator Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment
Pathways		NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Blood protein levels ( 23696881) Body mass index ( 26426971)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	8 interacting genes: BAG3 BAG4 GEM GRB2 GTPBP3 MDFI PSMD2 ZRANB1
Entrez ID		2669	101060321
HPRD ID		11553
Ensembl ID		ENSG00000164949	ENSG00000260287
Uniprot IDs		P55040	Q6DHY5 Q6IPX1
PDB IDs		2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton	Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Adenyl-nucleotide Exchange Factor Activity Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Targeting To Mitochondrion Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of MRNA Modification Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Proteasome Storage Granule Protein-folding Chaperone Binding Autophagosome Organization Autophagosome Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Establishment Of Protein Localization Protein K29-linked Deubiquitination Positive Regulation Of Aggrephagy Protein K33-linked Deubiquitination Positive Regulation Of Supramolecular Fiber Organization Neurotrophin TRKA Receptor Binding Vacuole Organization Aggresome Assembly Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
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