GEM and BMP1

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		GEM	BMP1
Gene Name		GTP binding protein overexpressed in skeletal muscle	bone morphogenetic protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Immune Response Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Chromosome Organization Metaphase Plate Congression	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development
Pathways			Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		40 interactors: A2M AHCYL1 APOH BLZF1 BMP1 CCDC102B CCDC67 CLDN15 CLEC4G COG8 CTSL GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NL PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB	14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		2669	649
HPRD ID		11553	00209
Ensembl ID		ENSG00000164949	ENSG00000168487
Uniprot IDs		P55040	P13497
PDB IDs		2CJW 2G3Y 2HT6	3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex I Biogenesis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Protein Complex Assembly Mitochondrial Respiratory Chain Complex Assembly Regulation Of Complement Activation Intracellular Transport Regulation Of Protein Binding Spliceosomal Complex Disassembly Establishment Of Localization In Cell Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus
Tagcloud ?		annotation centralized clinvar coherent compilation consortium curates curation das elect empowering exome expandable freestanding gbrowse guid https informs interrogation lsdb mseqdr mtdna phenotyping prioritize secure shareholders suite tracks void	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Difference) ?		annotation centralized clinvar coherent compilation consortium curates curation das elect empowering exome expandable freestanding gbrowse guid https informs interrogation lsdb mseqdr mtdna phenotyping prioritize secure shareholders suite tracks void	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Intersection) ?