GEM and CTSL

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		GEM	CTSL
Description		GTP binding protein overexpressed in skeletal muscle	cathepsin L
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		NPAS4 regulates expression of target genes	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		2669	1514
HPRD ID		11553	00293
Ensembl ID		ENSG00000164949	ENSG00000135047
Uniprot IDs		P55040	P07711 Q5T8F0 Q9HBQ7
PDB IDs		2CJW 2G3Y 2HT6	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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