GEM and CLDN15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GEM	CLDN15
Description		GTP binding protein overexpressed in skeletal muscle	claudin 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle	Plasma Membrane Bicellular Tight Junction Membrane Lateral Plasma Membrane Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Structural Molecule Activity Identical Protein Binding Paracellular Tight Junction Channel Activity
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment	Monoatomic Ion Transport Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption
Pathways		NPAS4 regulates expression of target genes	Tight junction interactions
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	3 interacting genes: GEM PLPP6 SLC35B2
Entrez ID		2669	24146
HPRD ID		11553	13065
Ensembl ID		ENSG00000164949	ENSG00000106404
Uniprot IDs		P55040	P56746
PDB IDs		2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton	3'-phosphoadenosine 5'-phosphosulfate Transport 5'-adenylyl Sulfate Transmembrane Transport 3'-phospho-5'-adenylyl Sulfate Transmembrane Transport 3'-phosphoadenosine 5'-phosphosulfate Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Protein Prenylation Regulation Of Neutrophil Activation Phosphatidate Phosphatase Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Nucleotide Transmembrane Transport Spindle Midzone Chondroitin Sulfate Proteoglycan Metabolic Process Purine-containing Compound Transmembrane Transport Purine Nucleotide Transport Nucleotide Transport Adenine Nucleotide Transport Phospholipid Dephosphorylation Cholesterol Biosynthetic Process Phospholipid Catabolic Process Sterol Biosynthetic Process Calcium Channel Regulator Activity Nuclear Inner Membrane Metaphase Chromosome Alignment Endoplasmic Reticulum Membrane Proteoglycan Biosynthetic Process GDP Binding Carbohydrate Derivative Transport
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